Cocaine intoxication with

Nanji AA, Filipenko JD. (1984). Asystole and ventricular fibrillation associated with cocaine intoxication. Chest. 85(1) 132-33. 

At higher doses, cocaine can produce undesirable effects, including tremor, emotional lability, restlessness, irritability, paranoia, panic, and repetitive stereotyped behavior. At even higher doses, it can induce intense anxiety, paranoia, and hallucinations, along with hypertension, tachycardia, ventricular irritability, hyperthermia, and respiratory depression. In overdose, cocaine can cause acute heart failure, stroke, and seizures. Acute intoxication with cocaine produces these various clinical effects, depending on the dose these effects are mediated by inhibition of the dopamine transporter and in turn by the effects of excessive dopamine activity in dopamine synapses, as well as by norepinephrine and serotonin in their respective synapses. 

Repeated intoxication with cocaine may produce complex adaptations of the dopamine neuronal system, including both tolerance and, indeed, the opposite phenomenon, called sensitization or reverse tolerance. One example of reverse tolerance may be what happens to some abusers on repeated intoxication with cocaine at doses that previously only induced euphoria. In these cases, cocaine causes a behavioral... 

Of 279 patients who presented to a hospital emergency service between 1994 and 1998 with a first tonic-clonic seizure, 17 (6.1%) had seizures that were thought to be drug-related (5). The most common drug-induced causes were cocaine intoxication (6/17) and benzodiazepine withdrawal (5/17) followed by amfebutamone use (4/17). While one amfebutamone-associated seizure occurred in a 26-year-old woman without any other risk factors, the... 

The authors suggested that acute sexual excitement during cocaine intoxication can cause penile erection, with impaired detumescence. Cocaine can inhibit the reuptake of noradrenaline (by blocking transport in presynaptic sympathetic neurons), thus preventing sinusoidal contraction and the efflux of penile blood. 

Roth D, Alarcon FJ, Fernandez JA, Preston RA, Bourgoignie JJ. Acute rhabdomyolysis associated with cocaine intoxication. N Engl J Med 1988 319(ll) 673-7. 

WWW. emcdda.eu.int, Intoxications with cocaine adulterated with atropine in four EU Member States. Information from the EMCDDA and REITOX Early Warning System (Nov./Dec. 2004 - Feb. 2005)... 

About 60-75% of chronic cocaine abusers report severe headaches (93), which can resemble migraine migrainelike symptoms can include auras, visual field changes, and paraphasia (94). About 60-75% of chronic cocaine abusers report severe headaches (93,94). Of 21 patients who were admitted to hospital from January 1985 to December 1988 for acute headache associated with cocaine intoxication 15 had headaches with migrainous features in the absence of neurological or systemic complications (93). None had a history of cocaine-unrelated headaches or a family history of migraine, and all had a... 

Cohle SD, Lie JT. Dissection of the aorta and coronary arteries associated with acute cocaine intoxication. Arch Pathol Lab Med 1992 116(11) 1239 1. 

Petroff and co-workers reported a quantitative analysis of the H NMR spectra of six CSF samples from three patients. TTiese included a 34-year-otd man presenting with seizures several hours after injecting heroin and cocaine while intoxicated with alcohol, and a 7-month-old girl who presented as a febrile, cyanotic hypotensive in a coma. The H NMR spectrum of the CSF of the drug overdose victim showed clear and abnormally elevated signals for citrate, myo-inositol, creatinine/creatine and lactate. 

B. Lidocaine may produce additive effects with other local anesthetics. In severe cocaine intoxication, lidocaine theoretically may cause additive neuronal depression. 

Given the enormous importance of the human brain, one might think that our bodies would have evolved extensive safeguards to protect it from toxic compounds. Yet the brain is so easily intoxicated with some very common chemicals that we don t even question it. Alcohol, nicotine, caffeine, heroin, methamphetamine, cocaine—they... 

Identify the typical signs and symptoms of intoxication associated with the use of alcohol, opioids, cocaine/amphetamines, and cannabis, and determine the appropriate treatment measures to produce a desired outcome following episodes of intoxication. 

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