Rhabdomyolysis associated with

Myopathy and rhabdomyolysis associated with lovastatin-gemfibrozil combination therapy. JAMA 1990 264 71. 

Skeletal muscle effects In clinical trials, there was no excess of myopathy or rhabdomyolysis associated with ezetimibe compared with the relevant control arm (placebo or HMG-CoA reductase inhibitor alone). However, myopathy and rhabdomyolysis are known adverse reactions to HMG-CoA reductase inhibitors and other lipid-lowering drugs. 

Yokoyama M, Izumiya Y, Yoshizawa M, Usuda R. Acute rhabdomyolysis associated with troglitazone. Diabetes Care 2000 23(3) 421-2. 

Maltz HC, Balog DL, Cheigh JS. Rhabdomyolysis associated with concomitant use of atorvastatin and cyclosporine. Ann Pharmacother 1999 33(ll) 1176-9. 

Atmaca H, Sayarlioglu H, Kulah E, Demircan N, Akpolat T. Rhabdomyolysis associated with gemfibrozil-colchicine therapy. Ann Pharmacother 2002 36(11) 1719-21. 

Jacobson RH, Wang P, Glueck CJ. Myositis and rhabdomyolysis associated with concurrent use of simvastatin and nefazodone. JAMA 1997 277(4) 296-7. 

Spach DH, Bauwens JE, Clark CD, Burke WG. Rhabdomyolysis associated with lovastatin and erythromycin use. West J Med 1991 154(2) 213-5. 

Landesman KA, Stozek M, Freeman NJ. Rhabdomyolysis associated with the combined use of hydroxymethylglutaryl-coenzyme A reductase inhibitors with gemfibrozil and macrolide antibiotics. Conn Med 1999 63(8) 455-7. 

Nicotinic acid increased the risk of rhabdomyolysis associated with HMG-CoA reductase inhibitors (SEDA-19, 206 46). 

Peces R, Pobes A. Rhabdomyolysis associated with concurrent use of simvastatin and diltiazem. Nephron 2001 89(l) 117-8. 

Tal A, Rajeshawari M, Isley W. Rhabdomyolysis associated with simvastatin-gemfibrozil therapy. South Med J 1997 90(5) 546-7. 

Kahri AJ, Valkonen MM, Vuoristo MK, Pentikainen PJ. Rhabdomyolysis associated with concomitant use of simvastatin and clarithromycin. Ann Pharmacother 2004 38(4) 719. 

Zullino D, Brauchli S, Horvath A, Baumann P. Inappropriate antidiuretic hormone secretion and rhabdomyolysis associated with citalopram. Therapie 2000 55(5) 651-2. 

Koren W, Koren E, Nacasch N, Ehrenfeld M, Gur H. Rhabdomyolysis associated with clozapine treatment in a patient with decreased calcium-dependent potassium permeability of cell membranes. Clin Neuropharmacol 1998 21(4) 262 1. 

Roth D, Alarcon FJ, Fernandez JA, Preston RA, Bourgoignie JJ. Acute rhabdomyolysis associated with cocaine intoxication. N Engl J Med 1988 319(ll) 673-7. 

Two young patients with phencyclidine toxicity developed acute rhabdomyolysis and myoglobinuria, probably secondary to skeletal muscle injury due to an acute dys-tonic motor reaction (18) and 30 reported cases of rhabdomyolysis associated with acute renal insufficiency have been reviewed (19). 

Sjmptoms of rhabdomyolysis, associated with other disorders, occurred in two patients a few hours after glafenine (10). 

Rhabdomyolysis associated with interferon beta has been reported (61). 

Zaim S, Wiley DB, Albano SA. Rhabdomyolysis associated with naltrexone. Ann Pharmacother 1999 33(3) 312-13. 

Gibbs JM. A case of rhabdomyolysis associated with suxamethonium. Anaesth Intensive Care 1978 6(2) 141-5. 

Lombard J,Wong B,YoungJH. Acute renal failure due to rhabdomyolysis associated with cocaine toxicity. West J Med 1988 148 ... 

In this case example, the FDA s SRS + AERS database, through the end of the second quarter of 2005, was data mined to determine the lower 95% confidence interval limit of the EBGM scores (denoted as EB05), a measure of disproportional-ity, for rhabdomyolysis associated with the use of statins. The drugs of interest were atorvastatin, cerivastatin, fluvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin. The event of interest was rhabdomyolysis. 

Figures 40.2-40.5 show the frequency and EB05 scores, both total and cumulative by year, of rhabdomyolysis associated with the use of the statins. AEs in the FDA database are codified using the MedDRA dictionary. It is important to note that a single case report may contain more than one preferred term.

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