Clobazam

Clobazam (54, X = Cl) and related compounds (X = H, X = CF3) exist in the dioxo tautomeric form [80JHC551,87JCS(P2)1071], as do the analogous pyrazolo[3,4-h][l,4]diazepinediones (89JHC949). Tliese conclusions were mainly based on careful NMR studies including the use of lanthanide shift reagents (LSR). 

C 7H,5C1N205 22316-45-6) see Clobazam 7V-(4-chlara-2-nitrophenyl)-4-piperidinamine monohydro-bromide... 

Ci5H,iC1N202 22316-55-8) see Clobazam 4-7>-demethyIdaunomicinone I -ethylene acetal... 

CH3CI 74-87-3) see Atropine methonitrate Clobazam Dimethyltubocurarinium chloride Methylmethionine sulfonium chloride Naproxen Suxamethonium chloride methyl chloroacetate... 

Clobazam PM SHORT-CHAIN FATTY ACIDS Adjunct to other anti-epileptics. Partly as an anxiolytic... 

It is interesting to note that some 1,5-benzodiazepines such as 29 also possess CNS depressant activity. Treatment of substituted diphenylamine 26 with methyl malonyl chloride and reduction with Raney nickel led to orthophenylenediamine analogue 27. Sodium alkoxide treatment led to lactam formation (28), and alkylation in the usual way with NaH and methyl iodide produced clobazam (29). °... 

Parrott AC and Kentridge R (1982). Personal constructs of anxiety under the 1.5-benzodiazepine derivative clobazam, related to trait-anxiety levels of the personality. Psychopharmacology, 78, 353-357. 

Proenca P, Teixeira H, Pinheiro J, Marques EP, Vieira DN. 2004. Forensic intoxication with clobazam HPLC/DAD/ MSD analysis. Forensic Sci Int 143 205. 

The relative contribution of the active metabolites of the benzodiazepines to the overall therapeutic effect of the parent compound will depend on the concentration of the metabolite formed, its agonist potency at central benzodiazepine receptors and its lipophilicity. For example, after the chronic administration of diazepam, desmethyldiazepam accumulates in the brain. As this metabolite has potency at the benzodiazepine receptors equal to diazepam, the metabolite probably plays an important part in the overall action of diazepam. In the case of clobazam, however, even though the active metabolite desmethylclobazam is present in higher concentrations than the parent compound after chronic administration, it has a lower potency than clobazam and therefore is of less importance than the parent compound with regard to the anxiolytic effect. 

Carbam- azepine Valproic acid, Phenytoin, Clobazam Primidone, Pheno barbital... 

Benzodiazepines are the drugs of choice for status epilepticus (see above) however, development of tolerance renders them less suitable for long-term therapy. Clonazepam is used for myoclonic and atonic seizures. Clobazam, a 1,5-benzodiazepine exhibiting an increased anticonvulsant/seda-tive activity ratio, has a similar range of clinical uses. Personality changes and paradoxical excitement are potential side effects. 

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