Clobazam Cimetidine

Cimetidine Carbamazepine Clobazam Clonazepam Diazepam Phenytoin Valproate Risk of toxicity, particularly with phenytoin Inhibition of metabolism of the object drugs... 

Pullar T, Edwards D, Haigh JR, Peaker S, Feely MP. The effect of cimetidine on the single dose pharmacokinetics of oral clobazam and N-desmethylclobazam. Br J Chn Pharmacol 1987 23(3) 317-21. 

The combined serum level of diazepam and its active metabolite, des-methyldiazepam, was found to be increased by 75% in 10 patients who took cimetidine 300 mg four times daily for 2 weeks, but reaction times and other motor and intellectual tests remained unaffected. Other reports describe a rise in the plasma levels and/or AUC of diazepam (associated with increased sedation in one report ) due to cimetidine, and generalised incoordination has also been described in one individual. Cimetidine also raises the serum levels of adinazolam, alprazolam, chlordiazepoxide, clobazam, clorazepate, flu-razepam, nitrazepam, and triazolam, > > > and reduces the clearance of bromazepam. ... 

In contrast, cimetidine does not normally interact with clobazam, clo-tiazepam, lormetazepam, oxazepam or temazepam, although prolonged post-operative sedation was seen in one patient given oxazepam and cimetidine. ... 

Giigoleit H-G, Hajdu P, Hundt HKL, Koef n D, Malerc k V, Meyer BH, MuUerFO, Witte PU. Phaimac4 inetic aspects of the interaction between clobazam and cimetidine. EurJ Clin Pharmacol 9Z3) 25,139-42... 

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