Sodium Clobazam

It is interesting to note that some 1,5-benzodiazepines such as 29 also possess CNS depressant activity. Treatment of substituted diphenylamine 26 with methyl malonyl chloride and reduction with Raney nickel led to orthophenylenediamine analogue 27. Sodium alkoxide treatment led to lactam formation (28), and alkylation in the usual way with NaH and methyl iodide produced clobazam (29). °... 

Mode of action. Clobazam, like most of the benzodiazepines in clinical use, acts as an agonist on the benzodiazepine receptor site and thereby enhances GABAergic transmission. It is uncertain why the action of clobazam differs from the conventional benzodiazepines but it is possible that it could reflect differential binding to the GABA-A receptor sub-units. In addition to its action on GABA receptors, clobazam also reduced voltage-sensitive calcium ion conductance and sodium channel conductance. 

Sample preparation 1 mL Serum -t- 3 pL 20 ng/mL clobazam in methanol + 1 mL saturated sodium borate (pH adjusted to 11 with 6 M NaOH) -1- 5 ml n-hexane, mix for 2 min, centrifuge at 3000 g for 10 min. Separate organic phase, evaporate to dryness under a stream of helium at 30°, reconstitute in 20 pL mobile phase, inject a 10 pL aliquot. 

Sensorcaine - Bupivacaine Sentapent - Ampicillin Sent) - Clobazam Separln - Tolnaftate Sepazon -Cioxazolam Septaione - Chlorhexidine Septicoi - Chloramphenicol Septiderm - 4-Chioro-3,B-xyienol Septidron - Pipemidic acid Septilisin - Cephalexin Septfvon-Lavril -Triclocarban Septosi) Sulfamerazine Septra - Sulfamethoxazole Septra - Trimethoprim Septural - Piromidlc acid Sepyron - Cyclandelate Serai - Secobarbital sodium Ser-Ap-Es - Hydrochlorothiazide Ser-Ap-Es - Hydralazine HCI Ser-Ap-Es - Reserpine Serax Bisacodyl Serax - Oxazepam... 

In one study sodium valproate was reported to have no marked effeet on clobazam, but a study in children found that clobazam caused an 11% increase in the serum levels of valproate, despite a reduction of at least 10% in the valproate dosage. ... 

The half-life of oxiracetam was shorter in patients taking car-bamazepine and valproate or clobazam, but oxiracetam did not affect the serum levels of sodium valproate, carbamazepine or... 

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