Clobazam comparative studies

There is some evidence that higher than usual doses of lower potency BZDs may also be effective in treating PD ( 17, 25, 43, 81, 82, 83 and 84). For example, studies comparing alprazolam with lorazepam or diazepam indicate approximately equal efficacy ( 25, 43, 84, 85). In addition, there is evidence that higher than usual doses of diazepam, lorazepam, bromazepam, or clobazam may also block panic attacks. 

Bawden HN, Camfield CS, Camfield PR, Cunningham C, Darwish H, Dooley JM, Gordon K, Ronen G, Stewart J, van Mastrigt RCanadian Study Group for Childhood Epilepsy. The cognitive and behavioural effects of clobazam and standard monotherapy are comparable. Epilepsy Res 1999 33(2-3) 133-43. 

It is very difficult to assess and compare the results of the very many studies of this interaction because of the differences between the tests, their duration, the dosages of the benzodiazepines and alcohol, whether given chronically or acutely, and a number of other variables. However, the overall picture seems to be that benzodiazepines and related drugs including diazepam, " alprazolam,bromazepam, brotizolam, chlo-rdiazepoxide, " clobazam, dipotassium clorazepate, flunitrazepam, flurazepam, loprazolam, " lorazepam, lormetazepam, medazepam, midazolam, nitrazepam, " " oxazepam, temazepam, " triazolam, and zopiclone enhance the effects of alcohol i.e. cause increased drowsiness, impaired performance and driving skills. 

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