Carbamazepine Clobazam

Clobazam Carbamazepine Primidone Valproate Phenytoin Interaction inconsistent, usually of little clinical significance Inhibition of metabolism of the object drug... 

For simple and complex partial seizures and secondary generalized tonic-clonic seizures, the first line drugs are - carbamazepine, valproate and phenytoin. Second line drugs include - acetazolamide, clobazam, clonazepam, ethosuximide, felbamate, gabapentin, lamotrigine, levetiracetam, oxacarbamazepine, primidone, tiagabine, topiramate and vigabactin. 

For atypical absence, tonic and clonic seizures, first line treatment is with valproate and second line with acetazolamide, carbamazepine, clobazam, clonazepam, ethosuximide, felbamate, lamotrigine, oxacarbamazepine, phenobarbitone, phenytoin, primidone or topiramate. 

Negative myoclonus and more typical signs of carbamazepine intoxication (fatigue, ataxia, clumsiness) occurred in a 66-year-old man after he took add-on clobazam (10 mg/day) for 4 weeks (14). Plasma concentrations of carbamazepine (58 pmol/1) and carbamazepine-10,11-epoxide (19 pmol/1) were higher than before clobazam therapy, and his symptoms resolved quickly when carbamazepine dosage was reduced and clobazam was withdrawn. The interaction was confirmed on rechallenge. 

Canadian Study Group for Childhood Epilepsy. Clobazam has equivalent efficacy to carbamazepine and phenytoin as monotherapy for childhood epilepsy. Epilepsia 1998 39(9) 952-9. 

Genton P, Nguyen VH, Mesdjian E. Carbamazepine intoxication with negative myoclonus after the addition of clobazam. Epilepsia 1998 39(10) 1115-8. 

Valproate, clonazepam, or clobazam may be safer alternatives in patients who have had a rash from aromatic anticonvulsants. However, in a 41-year-old man a fixed drug eruption that occurred after phenytoin and carbamazepine also occurred after valproate (SEDA-22, 83). 

Cimetidine Carbamazepine Clobazam Clonazepam Diazepam Phenytoin Valproate Risk of toxicity, particularly with phenytoin Inhibition of metabolism of the object drugs... 

Simultaneous amitriptyline, clomipramine, desipramine, doxepin, fluoxetine, imipramine, maprotiline, metoclopramide, norfluoxetine, nortriptyline Noninterfering carbamazepine, chlordiazepoxide, clobazam, diazepam, flurazepam, flus-pirilene, haloperidol, lorazepam, nitrazepam, nordiazepam, oxazepam, perazine, pimozide, spiroperidol, trifluperidol Interfering fluvoxamine... 

Extracted acebutolol, acenocoumarol, acepromazine, aceprometazine, acetaminophen, ajmaline, albuterol, alimemazine, alminoprofen, alpidem, alprazolam, alprenolol, amisul-pride, amitriptyline, amodiaquine, amoxapine, aspirin, atenolol, benazepril, benperidol, benzocaine, benzoylecgonine, bepridil, betaxolol, bromazepam, brompheniramine, bumad-izone, bupivacaine, buprenorphine, buspirone, caffeine, carbamazepine, carbinoxamine, carpipramine, carteolol, celiprolol, cetirizine, chlorambucil, chlordiazepoxide, chlormeza-none, chlorophenacinone, chloroquine, chlorpheniramine, chlorpromazine, chlorpropamide, cibenzoline, cicletanine, clemastine, clobazam, clomipramine, clonazepam, clonidine, clorazepate, clozapine, cocaine, codeine, colchicine, (yamemazine, cyclizine, cycloguanil, cyproheptadine, c arabine, dacarbazine, daunorubicin, debrisoquine, demexiptiline, de-sipramine, dextromethorphan, dextromoramide, dextropropo3gq)hene, diazoxide, diclofenac, dihydralazine, diphenhydramine, dipyridamole, disopyramide, dosulepine, doxepin. 

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