Climacteric symptoms

Kiss E (1990). Adjuvant effect of cavinton in the treatment of climacteric symptoms. Therapia Hungarica (Budapest), 38, 170-173. 

Rutanen EM, Heikkinen J, Halonen K, Komi J, Lammintausta R, Ylikorkala O (2003) Effects of ospemifene, a novel SERM, on hormones, genital tract, climacteric symptoms, and quality of life in postmenopausal women a double-blind, randomized trial. Menopause 10(5) 433—439... 

Effects of Soy or Red Clover Derived Phytoestrogen on Climacteric Symptoms... 

De Aloysio D, Rovati LC, Giacovelli G, Setnikar I, Bottiglioni F. Efficacy on climacteric symptoms and safety of low dose estradiol transdermal matrix patches. A randomized, double-blind placebo-controlled study. Arzneimittelforschung 2000 50(3) 293-300. 

A Japanese study of the use of estriol 2 mg/day for 12 months in 68 postmenopausal women with climacteric symptoms showed a significant effect in relieving hot... 

Other climacteric symptoms include disturbances in the menstrual pattern, palpitation, headache, dizziness, numbness, myalgia, vaginal dryness and urinal tract symptoms. In over half of the climacterically symptomatic women also mental symptoms, such as anxiety, depression, decline in libido, lack of concentration, and memory impairment, are present these can exceed the severity of vasomotor symptoms. Further, sleeping problems are frequent during menopausal transition. They may show as exclusive symptoms or in addition to other climacteric symptoms. They are often attributed to nocturnal vasomotor symptoms. In menopausal women vasomotor symptoms are reported in 65-85 %, mental symptoms in 50-80 % and sleeping problems in 50-80% [23, 24], The duration of the symptoms has a wide variety. Vasomotor symptoms are experienced for 1-2 years in most of the women, but about 25 % will experience them for 5 years and even 9 % practically all lifelong [25, 26]. 

Several studies support an association between self-reported sleep problems and climacteric symptoms [5, 7, 23, 41], An European study with over 5000 women reported an unambiguous correlation between insomnia and vasomotor symptoms [23], In a more resent study with 12 600 women of a multi-ethnic origin in the USA, an odds ratio for sleeping problems in women with climacteric symptoms was 2.0 compared to asymptomatic women [5],... 

In addition to climacteric symptoms, sleep-disordered breathing should also be considered as a proposed mechanism for menopausal sleeping problems. The obstructive... 

Polo-Kantola P, Erkkola R, Irjala K, Helenius H, Pullinen S, Polo O (1999) Climacteric symptoms and sleep quality. Obstet Gynecol 94 219-224... 

No matter what degree of optimization can actually be achieved via this route, it must be remembered that vaginal delivery is only applicable to approximately 50% of the population. Thus it may be that the true potential of this route lies in the treatment of female-specific conditions, such as in the treatment of climacteric symptoms of the menopause etc., rather than more general applications such as insulin/peptide delivery. 

A 26-year-old woman with chronic myeloid leukemia developed busulfan-induced ovarian failure, with amenorrhea, climacteric symptoms, raised plasma concentrations of luteinizing and follicle-stimulating... 

Bastani B, GalU D, GeUens ME. Cimetidine-induced climacteric symptoms in a young man maintained on chronic hemodialysis. Am J Nephrol 1998 18(6) 538-40. 

Secreto, G. L.M. Chiechi A. Amadori R. Miceli E. Venturelli T. Valerio E. Marubini. Soy isoflavones and melatonin for the relief of climacteric symptoms A multicenter, double-blind, randomized study. Maturitas 2004, 47, 11-20. 

Osmers, R., M. Friede, E. Liske, et al. 2005. Efficacy and safety of isopropanolic black cohosh extract for climacteric symptoms. Obstet. Gynecol. 105(5) 1074-1083. 

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