Patch/matrix

Gerfen, C.R. (1989) The neostriatal mosaic striatal patch-matrix organization is related to cortical lamination. Science 246 385-388. 

In addition, and superimposed to the compartmental patch/matrix organization, corticostriatal projections determine a tripartite anatomical and functional subdivision of the striatum into motor, associative and limbic territories, which have been the subject of detailed investigations in both the monkey and the rat (reviewed by Joel and Weiner, 2000). 

Rgure 9.27 The four main types of transdermal patch matrix, reservoir, multilaminate and drug-in-adhesive designs. The matrix/reservoir systems are cut away to show the drug. Illustration courtesy of 3M. 

There are two other distinctive features of striatal output organization. The first is the segregation of the projections of the patch-matrix compartments of the striatum. This will be discussed in a later section. The second, which has been mentioned, is the dual projection zones of striatal inputs in both the globus pallidus and substantia nigra. As will be described these dual projection systems appear also in the organization of other components of the basal ganglia, including the projection of the subthalamic nucleus. 

The basis of striatal patch-matrix organization is the segregation of striatal medium spiny neurons that have projections to different components of the substantia nigra and entopeduncular nucleus (Gerfen 1984, 1985 Gerfen et al. 1985). Neurons in the patch compartment project to the location of the ventral tier dopamine neurons, whereas neurons in the matrix compartment project to the location of GABA neurons in the... 

Fig. 26. The relationship between the laminar organization of the cortex and the striatal patch-matrix compartments is diagrammed showing inputs from the prelimbic (A) and cingulate (D) cortices to the striatum. Corticostriatal neurons located in the deeper part of layer 5 (black cells in A and B) in each cortical area provide inputs directed to the patch compartment (black stippling in B,C, E and F), whereas corticostriatal neurons located in the superficial part of layer 5 (white cells in A and D) provide inputs directed to the matrix compartment (white stippling in B,C, E and F). Inputs from these cortical areas are somewhat greater to the patch compartment as compared to their inputs to the matrix compartment. The prelimbic and cingulate cortical areas provide inputs to a topographically related region in the striatum which overlaps to some extent for these two corticostriatal projections.

Thalamic afferents in the striatum from the parafascicular/intralaminar nuclei are organized relative to the patch matrix compartments (Beckstead 1985 Berendse et al. 1988 Herkenham and Pert 1981 Xu et al. 1991). Inputs from the parafascicular/ centromedian thalamic nuclei provide inputs directed to the matrix compartment. Inputs to the striatal patch compartment arise from more restricted parts of the intralaminar thalamic nuclei. 

Fig. 28. Summary diagram of the orgairization of the input-output organization of the striatal patch-matrix compartments.

CORTICAL ORGANIZATION RELATED TO STRIATAL PATCH-MATRIX COMPARTMENTS... 

Berendse HW, Voorn P, te Kortschot A, Groenewegen HJ (1988) Nuclear origin of thalamic afferents of the ventral striatum determines their relation to patch/matrix configurations in enkephalin-immunoreactivity in the rat. J. Chem. Neuroanat., 1, 3-10. 

Gerfen CR, Baimbridge KG, Thibault J (1987) The neostriatal mosaic III. Biochemical and developmental dissociation of patch-matrix mesostriatal systems. J. Neurosci., 7, 3935-3944. 

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