Cisapride

Cisapride (27) is effective in the treatment of re/Iux esophagitis and constipation, with a novel mechanism thought to involve acetylchohne release in the gut. It IS devoid of CNS and cardiac side effects [23]... [Pg.1123]

The synthesis of a benzamide with a somewhat more complex side chain starts by condensation of acid 144 with racemic cis-aminopiperidine 152. Removal of the benzyl group of 153 by hydrogenolysis gives the secondary amine 154. Alkylation on nitrogen with the halide 155 gives finally the dopamine antagonist, cisapride (156) [38,39]. [Pg.42]

Congenital Long QT syndrome Human-ether-a-go-go-related protein (HERG) E-4031, astemizole, cisapride... [Pg.1018]

C7H()N 100-46-9) see Amosulalol Bamidipine Beclamide Benperidol Betanidine Biotin Cisapride Dilevalol Guanoxan Moxifloxacin hydrochloride NebivOlol Nialamide Reproterol Sparfloxacin Sulbentine Viloxazine benzylamine hydrochloride (C7H,()C1N 3287-99-8) see Benzyl mustard oil 2-benzylaminoethanol... [Pg.2304]

CHjNaO 124-41-4) see Atorvastatin calcium Brinzolamide Ciprofloxacin Cisapride Dextrothyroxine Epirizole Hydroxyprogesterone Metaclazepam Moxifloxacin hydrochloride Moxonidine Oxcarbazepine Pantoprazole sodium Sulfadimethoxine Sulfalene Sulfamcthoxypyridazine Tacrolimus Vincamine sodium 3,4-(methylenedioxy)phenolate (CjHjNaOj 57f74-0i-5) sec Paroxetine sodium 4-nitrophenolate... [Pg.2441]

C4H10O3 149-73-5) see Cisapride Flosequinan Lamivudine Pyrimethamine Troglitazone trimethyl orthovalerate... [Pg.2451]

In some patients, torsades de pointes maybe of short duration and may terminate spontaneously. However, torsades de pointes may not terminate on its own, and if left untreated, may degenerate into VF and result in sudden cardiac death.13 Several drugs, including terfenadine, astemizole, and cisapride have been withdrawn from the United States market as a result of causing deaths due to torsades de pointes. [Pg.129]

Gastric emptying Metoclopramide Cisapride (limited access)... [Pg.260]

Most pharmacokinetic interactions in transplantation occur due to interactions with the CYP enzyme system however, several interactions have been shown to occur via alternative mechanisms. One of the most notable is that seen between tacrolimus and some of the prokinetic agents. Cisapride and metoclopramide have been shown to increase the absorption of tacrolimus by enhancing gastric emptying.41... [Pg.843]

Antihistamine astemizole, terfenadine Estrogen ethinyl estradiol GI cisapride... [Pg.65]

Kerrigan DD, Taylor ME, Read NW, Johnson AG Acid, motility, and ulcers A comparison of cisapride with placebo in the prevention of duodenal ulcer relapse. Gut 1993 34 1042-1046. [Pg.19]

In some patients SIBO is caused by intestinal stasis secondary to motility defects, and the restoration of normal intestinal motility may represent an effective approach. Prokinetic agents have been shown to improve intestinal motility [ 15,16], and the use of this therapeutic approach has been shown to be effective in patients with scleroderma, low-dose octreotide proved to be useful in the reduction of bacterial overgrowth [17]. Unfortunately, cisapride was recently removed from the market due to car-diotoxicity, and, apart from an erythromycin analog without antibiotic effects which showed no effects in rats [18],... [Pg.104]

Camilleri M, Malagelada JR, Abell TL, Brown ML, Hench V, Zinsmeister AR Effect of six weeks of treatment with cisapride in gastropar-esis with intestinal pseudoobstruction. Gastroenterology 1989 96 704-712. [Pg.108]

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