Paracetamol Cisapride

Cyt 3A3/4 metabolizes clozapine, sertindole, quetiapine common substrates -tricyclic antidepressants, nefazodone, sertraline, carbamazepine, ethosuximide, terfenadine, benzodiazepines, diltiazem, nifedipine, verapamil, erythromycin, cyclosporine, lidocaine, quinidine, cisapride, paracetamol. Common inhibitors -nefazodone, fluvoxamine, fluoxetine, ketoconazole. 

Recently, sodium bicarbonate has been used as a gasforming agent in alginate raft systems and in floating, controlled-release oral dosage forms of furosemide and cisapride. Tablet formulations containing sodium bicarbonate have been shown to increase the absorption of paracetamol, and improve the stability of levothyroxine. ... 

Rowbotham DJ, Parnacott S, Nimmo WS. No effect of cisapride on paracetamol absorption after oral simultaneous administration. EurJClin Pharmacol (1992) 42, 235-6. 

Itoh H, Nagano T, Takeyama M. Cisapride raises the bioavailability of paracetamol by inhibiting its glucuronidation in man. JPharm Pharmacol (2001) 53, 1041-45. 

---