Ciprofloxacin hemolytic anemia with

Allergic reactions (e.g., rashes, urticaria, and eosino-philia) have been observed. These drugs have occasionally been associated with cholestatic jaundice, blood dyscrasias, hemolytic anemia, hypoglycemia, and nephrotoxicity. Recently the use of ciprofloxacin for prophylaxis protection against anthrax infection has been associated with damage to muscle ligaments. 

In over 33 000 patients treated with ciprofloxacin, norfloxacin, or ofloxacin, no case of hemolytic anemia was discovered by prescription event monitoring (19). However, ciprofloxacin has been associated with hemolysis in combination with a severe skin reaction in a young adult (41). 

Hematologic An 88-year-old woman with glucose-6-phosphate dehydrogenase (G6PD) deflciency developed an acute hemolytic anemia soon after the use of intravenous ciprofloxacin 500mg/day for fever and diarrhea after chemotherapy for colon cancer [25 ]. She had shortness of breath, cyanosis, and a fall in hemoglobin from 11.1 to 6.4 g/dl. 

A 53-year-old white man was given chemotherapy for acute lymphoblastic leukemia and after 4 weeks recovered his blood cell count but developed a fever and was given oral ciprofloxacin 500 mg bd. After four doses he developed the typical features of hemolytic-uremic syndrome with microangiopathic hemoljdic anemia. The ciprofloxacin was withdrawn, and he received five sessions of plasma exchange. He recovered completely. 

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