Prescription event monitoring PEM

If analysis of the frequency of adverse events is based on prescription event monitoring (PEM), the rates of adverse events are usually substantially lower. In one study, over 11 000 patients taking each antibiotic were monitored (19). Among the fluoroquinolones, ciprofloxacin, norfloxacin, and ofloxacin were used. Adverse events resulted in withdrawal of norfloxacin or ofloxacin in under 1% of patients (19). 

Using the method of prescription event monitoring (PEM), the incidence densities of adverse effects per 1000 patient-months of exposure have been measured in 14 522 patients (2). Most were hypertensive (63%). During treatment months 2-6, the commonest adverse... 

Prescription event monitoring (PEM) is a pharmacoepidemiological system which uses the cohort design and was developed in England around 1980. It is mostly focused on new medicines, particularly those used for chronic diseases and is complementary to spontaneous reporting as a method of identifying unexpected ADRs. 

Prescription-event monitoring (PEM) A pharmacoepidemio-logical smdy in which a cohort of users of a medicine is identified from prescriptions and followed-up for a defined period (often 6-12 months) so as to identify all adverse events occurring in the early post-treatment period. The data are potentially useful for... 

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