1,8-Cineole mints

A number of organic compounds, such as N, N-dimethylaniline-present in amoxycillin trihydrate cephalexin cloxacillin sodium dicloxacillin sodium 2-ethylhexanoic acid-in amoxycillin sodium 4-chlorophenol-in clofibrate acetone and butanol-in daunorubacin hydrochloride cineole limonene ratio-in dementholised mint oil etc ... 

Limonene (3) a//3-Pinene (4, 5) Linalool (6) Menthol (7) Geraniol (8) Sweet orange (R) Pine wood ((+)-aa, (-)-ff) Ho (R), rosewood ( ) Japanese mint (-) Palmarosa Citronellol (9) Citronellal (10) 1,8-Cineole (1) Citral (11) Eugenol (2) Geranium (S) Eucalyptus (E citriodora, ), citronella (R) Eucalyptus (E globulus) Lemongrass, Litsea cubeba Glove... 

America, and Japan. The main constituents of the essential oil are a- and p-pinene, limonene, cineol, ethyl amylcarbinol, menthone, menthol, isomenthol, menthyl acetate, and piperitone. It has a strong mint odor with a sweet balsam taste masked by a strong cooling effect. It is widely used in foods, as well as in liquid pharmaceuticals, to 8000 ppm. 

Carveol (5) is one of the minor components responsible for the odour of spearmint, and is easily prepared by reduction of carvone. Isopulegol (6) is prepared from citronellal, as discussed in the section on menthol below, and is a precursor to other materials in the group. The phenols carvacrol (7) and thymol (8) are important in some herbal odour types, but the major use for thymol is as a precursor for menthol q.v. Piperitone (9) and pulegone (10) are strong minty odorants, the latter being the major component of pennyroyal oil. 1,8-Cineole (11) is the major component of such eucalyptus oils as Eucalyptus globulus. These oils are inexpensive and so there is no need to prepare cineole synthetically. Menthofuran (12) is an important minor component of mint oils and can be prepared from pulegone. 

Three monoterpenoid ethers are shown in Figure 6.19.1,8 Cineole (98), more commonly referred to simply as cineole, comprises up to 95% of the oil of Eucalyptus globulus and about 40%-50% of cajeput oil. It also can be found in an extensive range of other oils and often as a major component. It has antibacterial and decongestant properties and consequently, eucalyptus oil is used in various paramedical applications. Menthofuran (99) occurs in mint oils and contributes to the odor of peppermint. It is also found in several other oils. Rose oxide is found predominantly in rose and geranium oils. There are four isomers, the commonest being the levorotatory enantiomer of cis rose oxide (100). This is also the isomer with the lowest odor threshold of the four. 

The EO of Ziziphora clinopodioid.es ssp. rigida (blue mint bush) was isolated by hydrodistillation of the dried aerial parts, which was collected during the anthesis. The main compounds are thymol and 1,8-cineole with a content of 8% and 2.7%, respectively. Different extracts were tested by the DPPH assay to determine the antioxidative activity and showed that the free radical scavenging activity of the menthol extract was superior to all other extracts. Polar extracts exhibited stronger antioxidant activity than nonpolar extracts (Salehi et al., 2005). 

Two species produce phytotoxic monoterpenes Conradina canescens contains a mixture of monoterpenes, including 1,8-cineole, camphor, and bomeol (Williamson et al. 1989). Calamintha ashei contains a mixture of menthofuran monoterpenes (Tanrisever et al. 1988 Macias et al. 1989 Weidenhamer et al. 1994). Both species are mints, and presumably contain the terpenes in glandular tri-chomes on the leaf surface. Studies of the solubility of these compounds showed that their aqueous solubility is far in excess of their toxicity (Weidenhamer et al. 1993), which is necessary if these compounds are to be transported to the soil in aqueous solution by precipitation throughfall. 

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