Cimetidine Aspirin

Drugs that may interact include antacids, cimetidine, aspirin, digoxin, phenytoin, and theophylline. 

Cimetidine Aspirin (high doses) Cholestyramine Diuretics... 

Drugs that may affect rimantadine include acetaminophen, aspirin, and cimetidine. 

Several drug interactions involving amantadine and rimantadine are clinically significant. Anticholinergic drugs can potentiate the toxicity of amantadine. Thiazide-triamterene, trimethoprim-sulfamethoxazole, quinine, and quinidine increase plasma amantadine levels. Cimetidine decreases rimantadine clearance, and aspirin and acetaminophen decrease rimantadine plasma levels. 

Warfarin antagonists include vitamin K, barbiturates, glutethimide. rifampin, and cholestyramine. Warfarin potentiators include phenylbutazone. oxyphenbutazone, anabolic steroids, clofibrate, aspirin, hepatotoxins, disnlfirain, and metronidazole. In patients undergoing anticoagulation therapy with warfann, it has been found that cimetidine (used in therapy of duodenal ulcer) may increase anticoagulant blood levels and consequently prolong the prothrombin time. 

Correct choice = A. Rifampin induces the hepatic mixed function oxidases that metabolize warfarin. Platelet inhibitors, such as aspirin, increase the anticoagulant effect of warfarin. Phenylbutazone can transiently increase the level of free warfarin by displacing it from the plasma albumin binding site. Cimetidine inhibits warfarin metabolism and causes potentiation of the anticoagulant. Disulfiram inhibits warfarin metabolism. 

ALCOHOL CALCIUM CHANNEL BLOCKERS 1. Acute alcohol ingestion may t hypotensive effects. Chronic moderate or heavy drinking 1 hypotensive effects 2. Verapamil may t peaked serum concentration and prolong the effects of alcohol 1. Additive hypotensive effect with acute alcohol excess. Chronic alcohol excess is associated with hypertension 2. Uncertain at present, but presumed to be due to inhibition of the hepatic metabolism of alcohol, a mechanism similar to that with cimetidine, ranitidine and aspirin 1. Monitor BP closely as unpredictable responses can occur. Advise patients to drink alcohol only in moderation and to avoid large variations in the amount of alcohol drunk 2. Warn patients about potentiation of the effects of alcohol, particularly the risks to driving... 

Guth P H, Aures D, Paulsen G 1979 Topical aspirin plus HCI gastric lesions in the rat. Cytoprotective effect of prostaglandin, cimetidine and probanthine. Gastroenterology 76 88-93... 

Clinically important, potentially hazardous interactions with allopurinol, amiodarone, aspirin, cimetidine, danazol, disulfiram, econazole, heparin... 

Clinically important, potentially hazardous interactions with allopurinol, amiodarone, amobarbital, anabolic steroids, anti-thyroid agents, aprobarbital, aspirin, barbiturates, bivalirudin, butabarbital, butalbital, cimetidine, clofibrate, clopidogrel, cyclosporine, delavirdine, disulfiram, fenofibrate, fluconazole, gemfibrozil, glutethimide, imatinib, itraconazole, ketoconazole, levothyroxine, liothyronine, mephobarbital, methimazole, metronidazole, miconazole, penicillins, pentobarbital, phenobarbital, phenylbutazones, piperacillin, prednisone, primidone, propylthiouracil, quinidine, quinine, rifabutin, rifampin, rifapentine, rofecoxib, salicylates, secobarbital, sulfinpyrazone, sulfonamides, testosterone, thyroid, zileuton... 

Clinically important, potentially hazardous interactions with aluminum, aminophylline, aspirin, chlorambucil, cimetidine, clarithromycin, cyclophosphamide, cyclosporine, dicumarol, diuretics, docetaxel, estrogens, grapefruit juice, indomethacin, influenza vaccines, itraconazole, ketoconazole, lansoprazole, live vaccines, methotrexate, montelukast, omeprazole, oral contraceptives, pancuronium, phenobarbital, phenytoin, ranitidine, rifampicin, rifampin, timolol, tolbutamide, vitamin A... 

Following oral administration, rimantadine is extensively metabolized in the liver, with <25% of the dose excreted in the urine as unchanged drug. Three hydroxy-lated metabolites have been found in plasma. These metabolites, an additional conjugated metabolite, and parent drug account for 74% of a single 200 mg dose excreted in urine over 72 hours. Acetaminophen and aspirin reduce, whereas cimetidine increases, the plasma level of rimantadine. 

Copper(II)(salicylate)2 was also shown to be more effective than cimetidine in preventing ulcers induced by aspirin, indomethacin or cold-stress Table 6.21) [263],... 

Table 6.21. COMPARISON OF Cu(II)(SALICYLATE)2 AND CIMETIDINE, GIVEN ORALLY, IN PROTECTING AGAINST GASTRIC LESIONS PRODUCED BY ORAL ULCEROGENIC DOSES OF ASPIRIN (2.22 mmol/kg), INDOMETHACIN (56 /xmol/kg), AND COLD-STRESS IN RATS [265]...

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