Chronic obstructive pulmonary disease randomized controlled trials

Vestbo J, Sorensen T, Lange P, Brix A, Torre P, Viskum K. Long-term effect of inhaled budesonide in mild to moderate chronic obstructive pulmonary disease a randomized controlled trial. Lancet 1999 353 1819-23. 

Paggiaro PL, Dahle R, Bakran I, et al. Multicentre, randomized, placebo-controlled trial of inhaled fluticasone propionate in patients with chronic obstructive pulmonary disease. International COPD Study Group. Lancet 1998 351 773-780. 

Calverly P, Pauwels R, Vestbo, J, et al. Combined salmeterol and fluticasone in the treatment of chronic obstructive pulmonary disease A randomized, controlled trial. Lancet 2003 361 449 56. 

Hawkins NM, Macdonald MR, Petrie MC, Chalmers GW, Carter R, Dunn FG, McMurray JJV. Bisoprolol in patients with heart failure and moderate to severe chronic obstructive pulmonary disease a randomized controlled trial. Eur J Heart Fail 2009 11 684-90. 

Cerda B, Soto C, Albaladejo MD, et al. Pomegranate juice supplementation in chronic obstructive pulmonary disease a 5-week randomized, double-blind, placebo-controlled trial. Eur J Clin Nutr. 2006 60 245-253. 

The association between the use of inhaled glucocorticoids and pneumonia in patients with chronic obstructive pulmonary disease (COPD) was reviewed in SEDA-32 (p. 311). More data have appeared. A meta-analysis of 11 randomized controlled trials that lasted at least 6 months, involving... 

Placebo-controlled studies In a randomized placebo-controlled trial of bosentan in 30 patients with severe chronic obstructive pulmonary disease (COPD) without evidence of severe pulmonary hypertension at rest there was no evidence of improved exercise capacity in fact, hypoxemia and functional status deteriorated [84 ]. 

Krishan JA, Moore D, Robeson C, et al. A prospective controlled trial of a protocol-based strategy to discontinue mechanical ventilation. Am J Respir Crit Care Med 2004 169 673-678. Nava S, Amlnosino N, Clini E, et al. Noninvasive mechanical ventilation in the weaning of patients with respiratory failure due to chronic obstructive pulmonary disease. A randomized controlled trial. Ann Intern Med 1998 128 721-728. 

Bourjeily-Habr G, Rochester CL, Palermo F, et al. Randomized controlled trial of transcutaneous electrical muscle stimulation of the lower extremities in patients with chronic obstructive pulmonary disease. Thorax 2002 57 1045-1049. 

Steiner MC, Barton RL, Singh SJ, et al. Nutritional enhancement of exercise performance in chronic obstructive pulmonary disease a randomized controlled trial. Thorax 2003 58 745-751. Cai B. Effect of supplementing a high-fat, low-carbohydrate enteral formula in COPD patients. Nutrition 2003 19 229-232. 

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