Chromosome aberrations rabbits

Investigations with Animals. A further support of the hypothesis described above can be found in investigations carried out with animals Leonard et al. (1979) found in an area with high natural radioactivity in France a small but significant increase of chromosome aberrations in the lymphocytes of rabbits. The rabbits were kept in a hut for 12 months, and received up to 0.7 Gy/year from gamma rays together with more than 6 Gy alpha doses from radon and daugthers. Further experiments with rabbits at radon exposure under controlled conditions have shown that the chromosome... 

Loveday, K.S., Lugo, M.H., Resnick, M.A., Anderson, B.E. Zeiger, E. (1989) Chromosome aberrations and sister chromatid exchanges in Chinese hamster ovary cells in vitro. II. Results with 20 chemicals. Environ, mol. Mutag., 13, 60-94 Marty, M.S., Neeper-Bradley, T.L., Neptun, D.A. Carney, E.W. (1999) Developmental toxicity of diethanolamine applied cutaneously to CD rats and New Zealand White rabbits. Regul. Toxicol. Pharmacol, 30, 169-181... 

Prenatal and postnatal development primate Genetic toxicology Ames test, micronucleus assay in mice Carcinogenicity none Developmental rats, rabbits Genetic toxicology Ames test, human lymphocyte chromosomal aberration assay Carcinogenicity short-term experiments in rodents (i.e., not standard 2-year study)... 

Developmental rats, rabbits Prenatal and postnatal development none Genetic toxicology Ames test, in vitro mammalian chromosome aberration test in V79 Chinese hamster cells, and in vivo mammalian erythrocyte micronucleus test in rats... 

Developmental rats, rabbits Prenatal and postnatal development rats Genetic toxicology Ames tests, mouse lymphoma cell forward gene mutation test, human peripheral blood lymphocyte chromosome aberration test, in vivo micronucleus test in mice and ex vivo UDS test in rat liver hepatocytes... 

Azathioprine gave positive results in the Ames Salmonella typhimurium mutagenicity assay, both with and without metabolic activation, in the TAIOO strain. Negative results were found for the TA98 strain under similar test conditions. Azathioprine has been shown to induce chromosomal aberrations in human and rabbit lymphocytes in vitro, however, it did not induce sister chromatid exchanges in either... 

Chronic and subchronic exposure of rats to propylene oxide by inhalation induced respiratory cell hyperplasia, irritation and toxicity in the nasal epithelium, at a concentration of 300 ppm or higher. No adverse effects on reproduction were observed in rats or rabbits exposed to propylene oxide at up to 500 ppm. In vivo studies in rodents of dominant lethal mutations, sperm abnormalities, micronuclei, chromosomal aberrations, and sister chromatid exchanges... 

Evidence of chromosomal aberrations was equivocal in an animal study. Rabbits exposed to high natural background levels of radon-222 (12 WLM) for over 28 months displayed an increased frequency of chromosomal aberrations (Leonard et al. 1981). However, when a similar study was conducted under controlled conditions (10.66 WLM), chromosomal aberrations were not found. According to the authors, the increased chromosomal aberrations in somatic cells of rabbits exposed to natural radiation were mainly due to the gamma radiation from sources other than radon. 

Oral Rat Mouse Intraperitoneal Rat Mouse Subcutaneous Rat Mouse Intravenous Mouse Dog Dermal Rabbit Cytogenetic analysis In vitro In vivo Ames test Chromosome Rat bone —S9 +S9 aberrations SCE marrow ... 

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