Chromoglycate

Chromogenic development process, 1, 369-373 Chromogens donor-acceptor, 1, 329 Chromoglycic acid sodium salts... 

Two reports [371, 372] of trials using disodium chromoglycate without isoprenaline confirmed that the drug possessed the beneficial properties claimed and that the dry powder could, in the absence of isoprenaline, give rise to transient pulmonary irritation. 

As a nasal decongestant in allergic rhinitis, with or without the addition of antazoline or sodium chromoglycate. 

Can be used as a supportive therapy with antibiotics, secretomucolytics, corticosteroids, physiological saline and disodium chromoglycate. 

Since the discovery of sodium chromoglycate (DSCG), a drug which is useful in the treatment of human asthma, several isosteric or structurally related bisbenzofuran systems have been synthesized. A recent example is 6,6 -[(2-hydroxypropane-l,3-diyl)bis(oxy)]-bis-(3-hydroxy-2-benzofurancarboxylic acid) diethyl ester trisodium salt trihydrate (510) (80JHC1U7). 

Pattenden and coworkers have recently evaluated the relative merits of LTA and electrochemical oxidation of phenolic compounds with particular reference to synthesis of the antiallergic compounds sodium chromoglycate (lOTAL 53) and proxicromil (54), which are used for the prophylactic treatment of asthma. The 2-carboxychromone moieties in the compounds (53) and (54) are synthesized from the appropriate 2, 6 -dihydroxyacetophenones. Oxidation of the 2 -hydroxyacetophenone (55) by LTA in (U-chloromethane gave almost exclusively the quinol acetate (56), which was subsequently converted to the 2, 6 -dihydroxyacetophenone (57), a precursor to proxicromil (54 Scheme 21). By contrast, electro-... 

Hartshorne, N.H. Woodart, G.D. Mesomorphism in the system disodium chromoglycate-water. Mol. Cryst. Liq. Cryst. 1973, 25, 343-368. 

Fio. 7. Current and lead compounds for the drug design case study (a) existing antiallergic, sodium chromoglycate (b) a lead compound. 

The discovery of dlsodlum chromoglycate (DSCG) in 1969 and its unique antiallergic activity ( ) has prompted many laboratories, including our own, to search for more potent, orally active compounds with this activity ( ). We reported in 1976 on a mildly active new series, the pyrantrlones (I) (3 ). 

With these methods, aerosol suspensions of epinephrine biianrate. steroid compounds, and bronchodilatants (such as salbutamol. phenylephrine, disodium chromoglycate) have been successfully prepared. 

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