Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Antiallergic compounds

Intravenous delivery to lungs of antiallergic compounds Sodium cromoglicate (Cromolyn sodium)... [Pg.552]

The synthesis of 2-alkoxymethylpteridines (antiallergic compounds) has also been achieved by the Taylor synthesis <1996EJM273> (Scheme 31). The 3-aminopyrazine-2-carboxamide 163 reacted with orthoesters to give 2-alkoxymethylpteridine derivative 164. Alternatively, 164 was synthesized by condensing 3-aminopyrazine-2-car-bonitrile 165 with the acetoxyamidine 166 followed by the base hydrolysis (Table 9). [Pg.945]

In addition to the chromone carboxylic acids mentioned in Section 2.23.8.1, a number of other chromones ha,ve shown promising activity as antiallergic compounds, for example 3-hydroxymethyl-8-methoxychromone (76MI22300), chromone-3-carboxylic acid (74CPB2959) and V-tetrazolyl chromonecarboxamides (78JMC1120). [Pg.707]

There are two types of histamine receptors HI receptors, which are blocked by agents such as diphenhydramine and other antiallergic compounds, and H2 receptors, which are blocked by cimetidine (Tagamet), ranitidine (Zantac), famotidine (Pepcid), and nizatidine (Axid). Cimetidine has no effect on most 11, receptor-mediated effects, such as bronchoconstriction. [Pg.593]

Pattenden and coworkers have recently evaluated the relative merits of LTA and electrochemical oxidation of phenolic compounds with particular reference to synthesis of the antiallergic compounds sodium chromoglycate (lOTAL 53) and proxicromil (54), which are used for the prophylactic treatment of asthma. The 2-carboxychromone moieties in the compounds (53) and (54) are synthesized from the appropriate 2, 6 -dihydroxyacetophenones. Oxidation of the 2 -hydroxyacetophenone (55) by LTA in (U-chloromethane gave almost exclusively the quinol acetate (56), which was subsequently converted to the 2, 6 -dihydroxyacetophenone (57), a precursor to proxicromil (54 Scheme 21). By contrast, electro-... [Pg.338]

Leprevost C, Capron M, De Vos C, Tomassini M, Capron A. Inhibition of eosinophil chemotaxis by a new antiallergic compound (cetirizine). Int Arch Allergy Appl Immunol 1988 87(1) 9-13. [Pg.313]

In the search for potential antiallergic compounds, the inhibition of ConA-induced histamine release from rat peritoneal mast cells has been measured as a monitor in separation and fractionation of active compounds [91]. On the basis of this in vitro test, ilexosides A, B, C and D (66-69), four novel 18,19-seco-ursane glycosides isolated from Ilex crenata... [Pg.657]

B. Potential antiallergic compounds derived from marine macroalgae... [Pg.270]

Although the discovery of these antiallergic compounds was a development of a study of the antispasmodic and especially the bronchodilator action of khellin, these chromones do not have a direct effect on smooth muscle and their therapeutic mode of action is of a different kind from that of khellin. They do not usually possess antihistaminic activity neither do they antagonise the actions of other spasmogens which may be associated... [Pg.107]

The active principle of Azelastine Eye Drops is Azelastine.HCl. Azelastine is a phthalazinone derivative which was synthetized and developed by ASTA Medica AG as an antiasthmatic and antiallergic compound. It is marketed as tablets and/or nasal spray in several countries as U.K., France, Spain, Germany, Japan, and others. A NDA is submitted in the United States. [Pg.287]


See other pages where Antiallergic compounds is mentioned: [Pg.6]    [Pg.189]    [Pg.308]    [Pg.436]    [Pg.177]    [Pg.139]    [Pg.332]    [Pg.641]    [Pg.221]    [Pg.51]    [Pg.171]    [Pg.156]    [Pg.11]    [Pg.145]    [Pg.158]    [Pg.293]    [Pg.105]    [Pg.267]    [Pg.139]    [Pg.85]    [Pg.86]   
See also in sourсe #XX -- [ Pg.305 ]




SEARCH



Antiallergic bronchodilator compounds

Antiallergic compounds, structures

Antiallergics

© 2024 chempedia.info