Sodium chromoglycate

As a nasal decongestant in allergic rhinitis, with or without the addition of antazoline or sodium chromoglycate. 

Since the discovery of sodium chromoglycate (DSCG), a drug which is useful in the treatment of human asthma, several isosteric or structurally related bisbenzofuran systems have been synthesized. A recent example is 6,6 -[(2-hydroxypropane-l,3-diyl)bis(oxy)]-bis-(3-hydroxy-2-benzofurancarboxylic acid) diethyl ester trisodium salt trihydrate (510) (80JHC1U7). 

Pattenden and coworkers have recently evaluated the relative merits of LTA and electrochemical oxidation of phenolic compounds with particular reference to synthesis of the antiallergic compounds sodium chromoglycate (lOTAL 53) and proxicromil (54), which are used for the prophylactic treatment of asthma. The 2-carboxychromone moieties in the compounds (53) and (54) are synthesized from the appropriate 2, 6 -dihydroxyacetophenones. Oxidation of the 2 -hydroxyacetophenone (55) by LTA in (U-chloromethane gave almost exclusively the quinol acetate (56), which was subsequently converted to the 2, 6 -dihydroxyacetophenone (57), a precursor to proxicromil (54 Scheme 21). By contrast, electro-... 

Fio. 7. Current and lead compounds for the drug design case study (a) existing antiallergic, sodium chromoglycate (b) a lead compound. 

Chromogenic development process, 1, 369-373 Chromogens donor-acceptor, 1, 329 Chromoglycic acid sodium salts... 

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