Chondrocytes, transplantation

Ganey T et al (2003) Disc chondrocyte transplantation in a canine model a treatment for degenerated or damaged intervertebral disc. Spine (Phila Pa 1976) 28(23) 2609-2620... 

Bae H, Kanim M, Zhao L (2008) Human fetal chondrocyte transplants for damaged intervertebral disc. Spine J 8(5) 928-938... 

Nehrer S, Domayer S, Dorotka R, Schatz K, Bindreiter U, Kotz R. Three-year clinical outcome after chondrocyte transplantation using a hyaluronan matrix for cartilage repair. Eur J Radiol 2006 57 3-8. 

Brittberg, M. Cartilage Repair, a collection of five articles on cartilaginous tissue engineering with an emphasis on chondrocyte transplantation. Institute of Surgical Sciences and Department of Clinical Chemistry and Institute of Laboratory Medicine, Goteborg University, Sweden, 2nd ed., 1996. 

Grande DA, Pitman ML, Peterson L, Menche D, Klein M. The repair of experimentally produced defects in rabbit articular cartilage by autologous chondrocyte transplantation. 1989 J Orthop Res. 7 208. ... 

One of the main open questions in chondrocyte transplantation is the fate of the implanted cells in vivo. Intended to establish prerequisites for such studies in animal models and to show the feasibility of this approach in... 

Litzke, L.E. et al.. Repair of extensive articular cartilage defects in horses by autologous chondrocyte transplantation, Ann. Biomed. Eng. 32, 57,2004. 

Madry H, Emkey G, Zurakowski D, Trippel SB. Overexpression of human fibroblast growth factor 2 stimulates cell proliferation in an ex vivo model of articular chondrocyte transplantation. / Gene Med 2004 6(2) 238-245. 

Langer, R. and Vacant , J.R (1993). Tissue engineering. Science 260 920-6. Brittberg, M., Lindahl, A., Nilsson, A., Ohlsson, C., Isaksson, O., and Peterson, L. (1994). Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N. Engl. J. Med. 331 889-95. 

The first tissue engineering product to be approved targeted the treatment of burns and consisted of keratinocytes cultivated in vitro, which form a tissue that is later transplanted to the patient. Beyond this product, others are already being commercialized for a wide range of applications. Examples are Carticel (marketed by Genzyme), which consists of chondrocytes employed in the treatment of cartilaginous defects caused by acute or repetitive traumas Apligraf (Novartis), used in the treatment of venous ulcer and DACS SC (Dendreon), utilized for reconstitution of the immune system after chemotherapy. 

Breast Lumpectomy, mastectomy Smooth muscle cells (SMC), fibroblast, chondrocytes PGA, PLA, PCL Replacement Elexible transplant with induced angiogenesis [28]... 

In a similar study, osteoblasts, osteocytes, and chondrocytes were grown on fibers obtained from a nonwoven mesh of polyglycolide. Vacanti and coworkers demonstrated that polyglycolide can be used as a matrix for bone and cartilage cell transplantation. A drawback to the use of these fibrous meshes was their insufficient compressive properties. In a study by Mooney... 

Cao. Y.L. Vacant , J.P. Paige. K.T. Upton, J. Vacant , C.A. Transplantation of chondrocytes utilizing a polymercell construct to produce tissue-engineered cartilage in the shape of a human ear. Plast. Reconstr. Surg. 1997. 100 (2). 297-302. 

Perka, C., Spitzer, R. S., Lindenhayn, K., Sittinger, M. Schultz, O. (2000) Matrix-mixed culture new methodology for chondrocyte culture and preparation of cartilage transplants. J Biomed Mater Res, 49, 305-11. 

We have had encouraging results with several cell types osteocytes, chondrocytes, hepatocytes, as well as intestinal mucosal and urothelial cells. Although many of the issues associated with cell transplantation... 

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