Choleretics

The compounds a-4-dimethylbenzyl camphorate diethanolamine, magnesium bis (4-methoxy-y-oxo-l-naphthalenebutyrate), and 5-(p-methoxyphenyl)-l,2-dithiol-3(3H)-thione, which were supposed to be cholaneretics, did not increase the secretion of natural bile. The infrared spectra indicated that the constituion of the bile components was different after administration of each of these choleretics. The common feature of each was the near disappearance of bands of sodium taurocholate (mentioned earlier). No change in the absorption of lecithin (1738 cm ) was caused by a-4-dimethylbenzyl camphorate diethanolamine, but this band disappeared in the bile after administration of the magnesium and thione compounds above. Some bands not observed in natural bile appeared instead, notably near 1420 and 800cm,  

Marked changes in the infrared spectrum of bile were found after the administration of the following compounds 2-(l-hydroxycyclohexyl) butyric acid, 1,4-0-dicaffeylquinic acid, or iV-(p-hydroxyphenyl) salicylamide. All these compounds caused new bands to occur. The first compound caused a new band at 830cm , the second compound caused new ones at 1396, 1261, and 1170cm , and the third produced new bands at 1512, 1175, 832, and 754cm . The absorption of bile acid weakened in intensity, but did not disappear, as was the case with some of the choleretics mentioned earlier. After the administration of the quinic acid compound, the absorption of lecithin characteristically disappeared. 

Chihara et al (1961) have found the changes in the infrared spectra of bile after the administration of each of the choleretics to be characteristic of these compounds and were able to confirm their reproducibility. The method was an effective means for assaying the potency of choleretics. 

Oi and Inaba (1967a) have determined sodium saccharin, dulcin, and sodium cyclamate in mixtures of these compounds. In methanol solution the bands at 1149 and 1512 cm are used for the determination of saccharin and dulcin, respectively, and in aqueous solution the band at 1194cm is used for the determination of cyclamate. These methods have been found to be quite useful for routine analyses. 

Oi and Miyazaki (1967) have described an infrared compensation method for the rapid determination of small amounts of isopropamide in pharmaceutical preparations containing aminopyrine, phenacetin, caffeine, and isopropamide. The key band used for isopropamide was 702cm in an acetone solvent. 

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Therapeutic Function Choleretic agent Chemical Name 3-n-Butoxy-l-phenoxv-2-propanol Common Name —... 

Therapeutic Function Choleretic Chemical Name a-Butylbenzenemethanol Common Name Phenylpentanol Structural Formula ... 

Tharapsutic Function Hepatotherapeutic, choleretic Chemical Name 4-Thiazolidinecarboxylic acid sodium salt Common Name ATC... 

A distantly related acid with a more highly functionalized ring shows choleretic rather than antiinflammatory activity. That is, the compound is useful in those conditions in which the flow of bile is to be increased. Construction of the thiazolone ring is accomplished by a method analogous to that used above to build the thiazole ring. Thus, condensation of ethyl mercaptoacetate with ethyl cyanoacetate leads to the thiazolinone (203) an intermediate such as 202, involving addition of mercaptide to the nitrile function, can be reasonably invoked. 

Bisoxatin Acetate Choleretic Piprozolin Cholinergic Agent Aceclidine Coccidiostats Oxyphenisatin Acetate... 

Azintamide (Azinthiamide, Biloral, Oragallin, Oragal, Rogalin, ST 9067, X-23 CAS 1830-32-6) (103) is a choleretic agent developed in Austria. 

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