Chloroquine sulphate

Ampicillin sodium Amylobarbitone Betamethasone Betamethasone valerate Carbenicillin disodium Chloroquine phosphate Chloroquine sulphate Cemetidine Clofazimine Clofibrate Clonidine... 

Orciprenaline Sulphate Trifluperidol Hydrochloride Ampicillin Sodium Disopyramide Phosphate Prednisolone Succinate Chloroquine Sulphate Guanoxan Sulphate Frusemide... 

The active component of many drugs, whether acid or base, is relatively insoluble and may present a problem in formulation. This is overcome by adding an acid to a base or vice versa the weight of the salt differs according to the acid or base component, i.e. chloroquine base 150 mg = chloroquine sulphate 200 mg = chloroquine phosphate 250 mg (approximately). Where there may be variation, therefore, the amount of drug prescribed is expressed as the weight of the active component, in the case of chloroquine, the base. 

Several 4-aminoquinolines have now been tested and hydroxychloroquine sulphate (Plaquenil XLV, R =Et, R =CH2-CH2-OH), a closely related derivative of chloroquine, is known to possess antirheumatic properties similar to those of chloroquine . Amodiaquine (Camoquin, XLVl, R=NEt2) also possesses activity but seems to be too toxic for routine use . . . However, the closely-related amopyroquin (Propoquin, XLVI, R=pyrrolidino) appears to possess desirable clinical activity without serious toxicity . Drugs of the 4-aminoquinoline type in most frequent use are chloroquine phosphate, 250-500 mg daily, chloroquine sulphate, 200-400 mg daily, and hydroxychloroquine sulphate, 400-600 mg daily . A striking feature of this therapy is that beneficial effects are often not apparent until... 

In rat-foot oedema tests, chloroquine sulphate in intraperitoneal doses of 10 mg/kg twice daily two days before and immediately prior to a formalin injection was found to be ineffective , whereas other workers have found chloroquine inhibitory in oral doses of 50 mg/kg . In these latter tests mepacrine, proguanil and primaquine, in oral doses of 50 mg/kg, were also effective. Chloroquine sulphate in doses of 10 mg/kg twice daily intraperitoneally for short or long term administration does not affect the development of generalized oedema produced by intraperitoneal dextran or egg-white . When administered chronically it reduces skin inflammation produced locally by chloroform, but is less effective than salicylates . ... 

Chloroquine sulphate is another salt of chloroquine [Nivaquin l, May Baker] which possesses almost similar actions to those of resochin. 

A total of 15 schizophrenic patients (in three groups of five) taking chlorpromazine 400 or 500 mg daily for at least 2 weeks were given single doses of either chloroquine sulphate 400 mg, amodiaquine hydrochlo-... 

Jolanki R, Alanko K, Pfaffli P, Estlander T, Kanerva L (1997) Occupational allergic contact dermatitis from 5-chloro-i-methyl-4-nitroimidazole. Contact Dermatitis 36 53-54 Kanerva L, Estlander T, Jolanki R (1994) Occupational skin allergy in the dental profession. Dermatol Clin 12 517-532 Kanerva L, Alanko K, Estlander T, Sihvonen T, Jolanki R (1997) Occupational allergic contact urticaria from chloramine-T solution. Contact Dermatitis 37 180-181 Keller K, Schwanitz HJ (1992) Combined immediate and delayed hypersensitivity to mezlocillin. Contact Dermatitis 27 348-349 Kellett JK, Beck MH (1984) Contact sensitivity to chloroquine sulphate. Contact Dermatitis 11 47 Klijn J (1984) Contact dermatitis from spironolactone. Contact Dermatitis 10 105... 

Kellet J, Beck M (1984) Contact sensitivity to chloroquine sulphate. Contact Dermatitis 11 47 Kleine-Natrop H, Richter G (1980) Arbeitsdermatosen in der pharmazeutischen Industrie. Derm Beruf Umwelt 28 8-10 Lahti A, Puurunen J, Hannuksela M (1990) Occupational contact allergy to 2,4-diamino-6-chloromethylpteridine hydrochloride an intermediate product in methotrexate synthesis. Contact Dermatitis 22 294... 

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