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Chloromethyl reaction

Benzilic acid rearrangement Benzoin reaction (condensation) Blanc chloromethylation reaction Bouveault-Blanc reduction Bucherer hydantoin synthesis Bucherer reaction Cannizzaro reaction Claisen aldoi condensation Claisen condensation Claisen-Schmidt reaction. Clemmensen reduction Darzens glycidic ester condensation Diazoamino-aminoazo rearrangement Dieckmann reaction Diels-Alder reaction Doebner reaction Erlenmeyer azlactone synthesis Fischer indole synthesis Fischer-Speior esterification Friedel-Crafts reaction... [Pg.1210]

Ghloromethylation. The reactive intermediate, 1-chloromethylnaphthalene [86-52-2] has been produced by the reaction of naphthalene in glacial acetic acid and phosphoric acid with formaldehyde and hydrochloric acid. Heating of these ingredients at 80—85°C at 101.3 kPa (1 atm) with stirring for ca 6 h is required. The potential ha2ard of such chloromethylation reactions, which results from the possible production of small amounts of the powerhil carcinogen methyl chloromethyl ether [107-30-2J, has been reported (21). [Pg.483]

Furan, 3-carboxy-2-methyl-4,5-trimethylene-synthesis, 4, 659 Furan, 2-chloro-reactions, 4, 78 Furan, 3-chloromercurio-synthesis, 4, 651 Furan, 2-chloromethyl-reactions... [Pg.629]

Dimroth rearrangement, 5, 438 Imidazolium chloride, 4-chloromethyl-reaction with poly(vinyl alcohol), 1, 306 Imidazolium chloride, 2,4,5-tri(diethylamino)-reduction, 5, 415 Imidazolium complexes, 7, 746... [Pg.659]

It is only recently that the chloromethylation reaction, well known in the benzene series, has been extended to isoxazoles. It has been thereby found that this reaction results in 4-chloromethyl derivatives (69), their yield decreasing as follows 5-phenyl > 3,5-dimethyl > 5-methyl > 3-methyl isoxazoles > isoxazole. To prove the position of the chloromethyl group these compounds were oxidized to the known isoxazole-4-carboxylic acids (70). It is especially noteworthy that pyridine and its homologs do not undergo chloromethylation. [Pg.387]

Mercuration and chloromethylation reactions as well as halogena-tion seem to proceed with preliminary coordination followed by substitution in the coordination compound. Such reactions as nitration and sulfonation in concentrated acids appear to proceed differently as evidenced by the substitution of the phenyl nucleus on nitration and by the sulfonation of phenylisoxazolcs. [Pg.390]

This is a chloromethylation reaction and is consequently listed at 11-24. However, in the course of the reaction formaldehyde is generated from the acetal. This reaction is not listed at 10-6 (hydrolysis of acetals), because it is not really a preparation of formaldehyde. [Pg.386]

The oxygen nucleophiles that are of primary interest in synthesis are the hydroxide ion (or water), alkoxide ions, and carboxylate anions, which lead, respectively, to alcohols, ethers, and esters. Since each of these nucleophiles can also act as a base, reaction conditions are selected to favor substitution over elimination. Usually, a given alcohol is more easily obtained than the corresponding halide so the halide-to-alcohol transformation is not used extensively for synthesis. The hydrolysis of benzyl halides to the corresponding alcohols proceeds in good yield. This can be a useful synthetic transformation because benzyl halides are available either by side chain halogenation or by the chloromethylation reaction (Section 11.1.3). [Pg.226]

Scheme 11.5 gives some examples of these acylation reactions. Entry 1 is an example of a chloromethylation reaction. Entry 2 is a formylation using carbon monoxide. Entry 3 is an example of formylation via to-chloromethyl ether. A cautionary note on this procedure is the potent carcinogenicity of this reagent. Entries 4 and 5 are examples of formylation and acetylation, using HCN and acetonitrile, respectively. Entries 6 to 8 are examples of Vilsmeier-Haack reactions, all of which are conducted on strongly activated aromatics. [Pg.1024]

The chloromethylation reaction can result in cross-linking additional to that produced by the DVB. Thus for anionic resins, the DVB content is not a reliable guide to pore size. [Pg.163]

The mechanism of the chloromethylation reaction is related to that of Friedel-Crafts alkylation and acylation and probably involves an incipient chloro-methyl cation, CH2C1 ... [Pg.1319]

Isoxazole, 3-chloro-5-hydroxymethyl-oxidation, 6, 27 Isoxazole, 4-chloromethyl-reactions, 6, 53 Isoxazole, 5-chloro-3-phenyl-reactions, 6, 58 Isoxazole, 3-cyano-reactions, 6, 30 Isoxazole, diacyl-synthesis, 6, 79 Isoxazole, 3,4-dialkyl-synthesis, 6, 83 Isoxazole, 3,5-dialkyl-synthesis, 6, 83 Isoxazole, 4,5-dialkyl-synthesis, 6, 83 Isoxazole, 3,5-diamino-2-amino-l-azirines from, 7, 89 Isoxazole, 3,5-diaryl-synthesis, 6, 63 Isoxazole, 2,5-dihydro-synthesis, 6, 79 Isoxazole, 4,5-dihydro-dehydrogenation, 6, 4... [Pg.687]

Alkylation of acetylacctone chelates is generally unsuccessful, but carbon—methylene bonds can be formed by chloromethylation, reaction with ethyl diazoacetate,reaction with thioacetals (equations 64, 65 and 66) and by the Mannich reaction (Scheme 73). The Mannich base can be quatemized with methyl iodide and converted by cyanide ion into a cyanomethyl-substituted chelate. [Pg.205]


See other pages where Chloromethyl reaction is mentioned: [Pg.374]    [Pg.650]    [Pg.735]    [Pg.890]    [Pg.919]    [Pg.260]    [Pg.534]    [Pg.580]    [Pg.103]    [Pg.100]    [Pg.534]    [Pg.1245]    [Pg.650]    [Pg.735]    [Pg.890]    [Pg.919]    [Pg.374]    [Pg.865]    [Pg.865]    [Pg.1474]    [Pg.95]    [Pg.68]    [Pg.650]   


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Blanc chloromethylation reaction

Chloromethyl

Chloromethyl methyl ether polystyrene reaction

Chloromethyl methyl ether, reaction

Chloromethyl phenyl sulfone reaction

Chloromethyl selenophenes reactions

Chloromethylated

Chloromethylated poly reactions

Chloromethylated polystyrene Wittig reactions

Chloromethylation

Chloromethylation Friedel-Crafts reaction

Ether, benzyl chloromethyl reaction with carbonyl compounds

Friedel-Crafts alkylation reactions chloromethylation

Polystyrene, chloromethylated amine reactions

Sulfone, chloromethyl phenyl Darzens-type reactions

Sulfoxide, chloromethyl phenyl Darzens-type reactions

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