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Side chain halogenation

Table 7 includes many structurally unique nonprotein amino acids with heterocyclic units as part of the structure. These amino acids are isolated from various sources and exhibit interesting bioactivities. In most cases, enzymatic modification of proline occurs through installation of hydroxyl groups, halogenated side chains, and alkyl side chains to give rise to the observed structural diversity. [Pg.38]

Aromatics with Halogenated Side Chain Aromatics with Halogenated Side Chain Benzyl Chloride Chlorotoluene, Alpha DDT Trichloro(chlorophenyl,4-bis) Ethane Arsenic... [Pg.3]

Benzyl chloride Chlorotoluene, alpha under Aromatics with Halogenated Side Chain Beryllium... [Pg.1265]

DDD Dichloro(chlorophenyl)-bis Ethane under Ring-Substituted Aromatics DDE Dichlorodiphenyldichloroethylene under Ring-Substituted Aromatics DDT Trichloro(chlorophenyl-l,4- bis) Ethane under Aromatics with Halogenated Side Chain Decane, n under Alkanes and Cyclic Alkanes... [Pg.1266]

Research carried out in the latter part of the war and continued in the post-war period has shown that the introduction of certain radicles into the molecules of these substances considerably increases their aggressive power. The entry of the NO -group into the benzene nucleus in the ortho-position to the side chain containing the halogen, and the introduction of the CN-group into the halogenated side chain itself are particularly efficacious. [Pg.128]

Aliphatic mono-halides, and aromatic hydrocarbons with halogen in side-chain, precipitate silver hdide on treatment with cold aqueous silver nitrate solution. [Pg.390]

Nitroamlines. Acetyl derivatives (p. 388), Benzoyl derivatives (p. 388). Diamines. Diacet> l derivatives (p. 388), Dibenzoyl derivatives (p. 388). Halogeno-hydrocarbons, a-Naphthyl ethers (from reactive halogen compounds, p. 391, and their Picratcs, p. 394), Nitro-derivatives (p.39i). Carboxylic acid (if oxidisable side chain) (p. 393). [Pg.403]

In the absence of catalysts, toluene when treated with chlorine (or bromine) at the boiling point, preferably with exposure to sunlight or other bright light source, undergoes halogenation in the side chain. The entrance of the first chlorine atom, for example, proceeds at a much faster rate than the entrance of the second chlorine atom so that in practice the major portion of the toluene is converted into benzyl chloride before appreciable chlorination of benzyl chloride occurs ... [Pg.534]

Oxidation of side chains. The oxidation of halogenated toluenes and similar compounds and of compounds with side chains of the type —CHjCl and —CH OH proceeds comparatively smoothly with alkaline permanganate solution (for experimental details, see under AromcUic Hydrocarbons, Section IV.9,6 or under Aromatic Ethers, Section IV,106). The resulting acid may be identified by a m.p. determination and by other teats (see Section IV,175). [Pg.544]

One of the virtues of the Fischer indole synthesis is that it can frequently be used to prepare indoles having functionalized substituents. This versatility extends beyond the range of very stable substituents such as alkoxy and halogens and includes esters, amides and hydroxy substituents. Table 7.3 gives some examples. These include cases of introduction of 3-acetic acid, 3-acetamide, 3-(2-aminoethyl)- and 3-(2-hydroxyethyl)- side-chains, all of which are of special importance in the preparation of biologically active indole derivatives. Entry 11 is an efficient synthesis of the non-steroidal anti-inflammatory drug indomethacin. A noteworthy feature of the reaction is the... [Pg.61]

Acyl Halides. Acyl halides, in which the hydroxyl portion of a carboxyl group is replaced by a halogen, are named by placing the name of the corresponding halide after that of the acyl radical. When another group is present that has priority for citation as principal group or when the acyl halide is attached to a side chain, the prefix haloformyl- is used as, for example, in fiuoro-formyl-. [Pg.24]

Side-Chain Derivatization. Reaction of thiophene with aqueous formaldehyde solution in concentrated hydrochloric acid gives 2-chloromethylthiophene [765-50-4]. This relatively unstable, lachrymatory material has been used as a commercial source of further derivatives such as 2-thiopheneacetonitrile [20893-30-5] and 2-thiopheneacetic acid [1918-77-0] (24). Similar derivatives can be obtained by peroxide, or light-catalyzed (25) halogenation of methylthiophenes, eg, Ai-bromosuccinimide/benzoylperoxide on 2-, and 3-methylthiophenes gives the corresponding bromomethylthiophenes. [Pg.20]

The reactions of benzyl chloride, benzal chloride, and ben zotricbl oride may be divided into two classes (/) reactions of the side chain containing the halogen and (2) reactions of the aromatic ring. [Pg.59]

Alkyl side chains in both pyrazines and quinoxalines are susceptible to halogenation by elemental halogens (28JCS1960, 68TL5931) and under radical conditions with NBS (72JOC511). Thus, bromination of 2-methylquinoxaline with bromine in the presence of sodium acetate... [Pg.167]

Nuclear halogenation of acetophenone depends on formation of the aluminum chloride complex. If less than one equivalent of aluminum chloride is used, side-chain halogenation occurs. 3-Bromoacetophenone has been prepared from 3-aminoaceto-phenone by the Sandmeyer reaction. The synthesis described here has been taken from work of the submitters, who have used it to prepare many 3-bromo- and 3-chloroacetophenones and benzaldehydes, as well as more highly halogenated ones (Notes 7 and 8). [Pg.10]

If chlorine and bromine are allowed to act upon an aromatic hydrocarbon like toluene, which has a side-chain, substitution may occur in the nucleus or the side-chain, according to the conditions. Generally speaking, in the cold and in presence of a halogen carrier, nuclear substitution occurs, Irut at a high temperatuie the halogen passes into the side-chain (see Piep. [Pg.272]


See other pages where Side chain halogenation is mentioned: [Pg.152]    [Pg.233]    [Pg.118]    [Pg.35]    [Pg.35]    [Pg.35]    [Pg.1265]    [Pg.256]    [Pg.236]    [Pg.339]    [Pg.152]    [Pg.612]    [Pg.118]    [Pg.22]    [Pg.54]    [Pg.765]    [Pg.765]    [Pg.77]    [Pg.23]    [Pg.152]    [Pg.233]    [Pg.118]    [Pg.35]    [Pg.35]    [Pg.35]    [Pg.1265]    [Pg.256]    [Pg.236]    [Pg.339]    [Pg.152]    [Pg.612]    [Pg.118]    [Pg.22]    [Pg.54]    [Pg.765]    [Pg.765]    [Pg.77]    [Pg.23]    [Pg.397]    [Pg.542]    [Pg.1059]    [Pg.305]    [Pg.292]    [Pg.225]    [Pg.934]    [Pg.448]    [Pg.473]    [Pg.254]    [Pg.273]    [Pg.302]    [Pg.303]   
See also in sourсe #XX -- [ Pg.799 ]




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