Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Alcohols transformations

The presence of catalyst residues, such as alkali hydroxide or alkali acetate, a by-product of the hydrolysis reaction, is known to decrease the thermal stability of poly(vinyl alcohol). Transforming these compounds into mote inert compounds and removal through washing are both methods that have been pursued. The use of mineral acids such as sulfuric acid (258), phosphoric acid (259), and OfXv o-phosphotic acid (260) has been reported as means for achieving increased thermal stability of the resulting poly(vinyl alcohol). [Pg.484]

An interesting appetite suppressant very distantly related to hexahydroamphetamines is somanta-dine (24). The reported synthesis starts with conversion of 1-adamantanecarboxylic acid (20) via the usual steps to the ester, reduction to the alcohol, transformation to the bromide (21), conversion of the latter to a Grignard reagent with magnesium metal, and transformation to tertiary alcohol 22 by reaction with acetone. Displacement to the fomiamide (23) and hydrolysis to the tertiary amine (24) completes the preparation of somantadine [6]. [Pg.4]

The oxygen nucleophiles that are of primary interest in synthesis are the hydroxide ion (or water), alkoxide ions, and carboxylate anions, which lead, respectively, to alcohols, ethers, and esters. Since each of these nucleophiles can also act as a base, reaction conditions are selected to favor substitution over elimination. Usually, a given alcohol is more easily obtained than the corresponding halide so the halide-to-alcohol transformation is not used extensively for synthesis. The hydrolysis of benzyl halides to the corresponding alcohols proceeds in good yield. This can be a useful synthetic transformation because benzyl halides are available either by side chain halogenation or by the chloromethylation reaction (Section 11.1.3). [Pg.226]

Although Schobein failed at marketing guncotton, researchers in France discovered that solvents such as diethyl ether and alcohol transformed nitrocellulose to a gel that could be molded into various shapes. Furthermore, spread thin on a flat surface, the gel dried to a tough, clear, transparent film. This workable nitrocellulose material was dubbed collodion, and its first application was as a medical dressing for cuts. [Pg.614]

Syntactic foams are chemically very stable. The EDS, SPS, and EDM materials gain less than 1.5 mass% if exposed to environments such as propyl alcohol, transformer oil, gasoline, or petroleum for up to 12 months, whilst their compression strength is reduced by less than 12-20% (Fig. 19). However, epoxy materials have poor resistance to acids or alkali, and are completely decomposed within 24 hours by benzene or acetone 1). [Pg.108]

Aluminophosphates (A1P04) were discovered in 198248 and a large amount of research has been directed towards the incorporation of various elements into the framework of these molecular sieves 49 A particular area of study is the oxidation of primary and secondary alcohols to the corresponding carbonyl compounds, which are useful synthetic intermediates. Traditionally, alcohol transformations are performed with stoichiometric chromium(VI) reagents.50 However, due to environmental problems associated with chromium-containing effluent, attention has focused on the use of chromium in conjunction with oxidizing agents such as tert-butyl hydroperoxide.51 Sheldon and co-workers... [Pg.193]

As we have seen above, alcohols and alkenes are produced routinely in the numerous reactions utilized in the formation of carbon-carbon bonds. These two functionalities are extremely useful for both the same-level oxidation interconversions and reduction-oxidation transitions (as stairways connecting different floors ). Therefore, it is not surprising to see an enormous number of methods developed to capitalize on the diverse options of alkene and alcohol transformations. These methods occupy a key place among the reactions known for isohypsic conversions of level 1 functionalities. [Pg.102]

Control experiments with 19a showed that in the absence of olefins hydrodimers were also formed but the reaction rate was reduced by about 90 %. Either the CdS itself (under photocorrosion) or the solvent must be involved in the oxidative step of this reaction. Accordingly, irradiation of CdS in a solution of 19a in different alcohols transforms the imine at different rates and the corresponding addition products 22a-e and the hydrodimer 23 are isolated (Figure 31). Except for methanol and 2-propanol, the products are racemic diastereomeric mixtures which are isolated in low yields (5-20 %) they are often mixed with the two-electron reduction product A-4-chlorobenzyl-4-chloroaniline. The major product in all reactions is the hydrodimer 23, obtained in yields of 10 % (MeOH), 28 % (BuOH), 29 % (PrOH), 42 %... [Pg.2642]

Although the preceding four reactions all obey the same stoichiometry for the carbonyl-alcohol transformation and thus involve the same variation in the oxidation state of the carbon atom, they are obviously different. Sodium reduction, in Eq. (1), involves single electron and proton transfers in a succession of separate steps conversely, in reactions (2) through (4), groups or atoms are transferred. [Pg.4]

TetraiodophenoUetraiodophlhalein. White powder insoluble in alcohol, Transformation region from 7.6 (colorless) to 9.4 (blue),... [Pg.115]

Scheme 18.12 Allylic alcohol sulfoxide and allylic sulfoxide alcohol transformations. ... Scheme 18.12 Allylic alcohol sulfoxide and allylic sulfoxide alcohol transformations. ...
Other Unsaturated Alcohols. The review mentioned above of carbometallation of alkynes, includes a survey of additions of alkenyl-metal derivatives to epoxides to give homoallylic alcohols. The zirconium-catalysed carboalumination of propargylic systems (Scheme 16) is also applicable to the homopropargylic to homoallylic alcohol transformation. ... [Pg.166]

Allylic Alcohols. Full details have appeared of the conversion of epoxides into allylic alcohols, mediated by trimethylsilyl trifluoromethanesulphonate (Scheme 4) (see 6,163 4,145), and this sequence is mentioned in a review of trialkylsilyl perfluoroalkanesulphonates as reagents opening of an epoxide ring occurs at the more substituted centre. The use of trimethylsilyl iodide for the epoxide-allyl alcohol transformation (5, 158) is discussed in a review of the preparation and applications of this reagent. ... [Pg.166]

Leaving this section of alcohol transformations it seems quite appropriate to indicate that nonenzymatic kinetic resolution of secondary alcohols is making good progress too [150]. [Pg.299]

Frequently, a given alcohol is more easily obtained than the corresponding halide so the halide-to-alcohol transformations are not extensively used for synthesis. [Pg.133]

Zhu Q, Kondo JN, Inagaki S, Tatsumi T. Catalytic activities of alcohol transformations over 8-ring zeolites. Top Catal 2009 52 1272-80. [Pg.260]

Apart from the described examples, other interesting alcohol transformations can occur where difierent reactions are combined to give new and sometimes unpredictable result. For instance, oxidation of one substrate and reduction of another one can lead to the same product, thus favoring... [Pg.128]

Intrinsic energy of FA can also be upgraded by means of etherification with short-chain alcohols, transformation of alkyl-furfuryl ethers into alkyl levulinates and esterification with short alkyl carboxylic acids. In the following, we wiU discuss the most... [Pg.369]

A good example of the qi/z-Evans aldol reaction is demonstrated by the Novartis synthesis of (+ymethylphenidate 204, a treatment for ADHD in children. Treatment of compound 199 with n-Bu2BOTf and DIPEA followed by aldehyde 200 afforded the 1,2-syn Aldol product 202. Initial Lewis acid complexation followed by deprotonation led to preferential (Z)-enolate formation. In this case, the use of a boron Lewis acid which can only coordinate to two heteroatoms led to syn stereochemistiy governed by a chair-like Zimmerman-Traxler transition state 201 (Scheme 14.72). Following mesylation of the secondary alcohol, the auxiliary was removed under reductive conditions and the resultant alcohol transformed into (-l-)-methylphenidate 204. [Pg.244]


See other pages where Alcohols transformations is mentioned: [Pg.341]    [Pg.285]    [Pg.176]    [Pg.107]    [Pg.604]    [Pg.133]    [Pg.237]    [Pg.163]    [Pg.421]    [Pg.585]    [Pg.91]    [Pg.421]    [Pg.175]    [Pg.261]    [Pg.281]    [Pg.159]   
See also in sourсe #XX -- [ Pg.136 ]

See also in sourсe #XX -- [ Pg.474 ]




SEARCH



Alcohols enzymatic transformations

Alcohols ester transformation into

Allyl alcohols transformation reactions

Allylic alcohol transformation

Dehydration of Alcohol with Ring Transformation

Enantioselective Enzymatic Transformations of Alcohols

General Procedure for Transformation of Alcohols to Ketones by Jones Oxidation

Transformation of Alcohols into Chlorides

Transformation of Propargyl Alcohols

Transformations with Alcohols and Phenols

© 2024 chempedia.info