Chloromethyl bromide

Synonyms AI3-15514 BRN 1730801 Bromomethyl chloride CB CBM CCRIS 817 Chlorobromomethane Chloromethyl bromide EINECS 200-826-3 Fluorocarbon 1011 Halon 1011 Methylene chlorobromide Mil-B-4394-B NSC 7294 UN 1887. 

Chloro-3-hydrox34oluene, see p-Chloro-ro-cresol 2-Chloroisopropyl ether, see Bis(2-chloroisopropyl) ether p-Chloroisopropyl ether, see Bis(2-chloroisopropyl) ether Chloromethane, see Methyl chloride (Chloromethyl)benzene, see Benzyl chloride Chloromethyl bromide, see Bromochloromethane Chloromethyl ether, see sym-Dichloromethyl ether (Chloromethyl)ethylene oxide, see Epichlorohydrin (2-Chloro-l-methylethyl) ether, see Bis(2-chloroisoprop-yl)... 

Beilstein Handbook Reference) AI3-15514 BRN 1730801 Bromochloromethane CCRIS 817 Chlorobromomethane Chloromethyl bromide EINECS 200-826-3 Fluorocarbon 1011 Halon 1011 HSDB 2520 Methane, bromochloro- Methylene chlorobromide MII-B4394-B Mono-chloro-mono-bromo-methane NSC 7294 UN1887. Has been used In refrigeration and fire retardents. Has been identified as an ozone-threatening chemicals and subjected to restrictions. Liquid mp = -87.9° bp = 68.0° d = 1,9344 poorly soluble in H2O, soluble in organic solvents. 

Synonyms CBM Chlorobromomethane Chloromethyl bromide Methane, bromochloro- Methylene chlorobromide Monochloromonobromomethane... 

N-Chloro-4-methylbenzenesulfonamide sodium salt. See Chloramine-T Chloromethyl bromide. See Bromochloromethane... 

Acetal, Copolymer (POM Copolymer) 9 Chloromethyl Bromide Polyethylene Terephthalate (PET) 2-3... 

Isoprene reacts with a-chloroalkyl ethers in the presence of ZnCl in diethyl ether from 0—10°C. For example,a-chloromethyl methyl ether at 10°C gives a 6 1 ratio of the 1,4-adduct, (F)4-chloro-l-methoxy-2-methyl-2-butene, to the 1,2-adduct, 2-chloro-l-methoxy-2-methyl-3-butene. Other a-chloroalkyl ethers react in a similar manner to give predominately the 1,4-addition product. A wide variety of aHyUc chlorides and bromides and a-chloroethers and esters add primarily 1,4- to isoprene in the presence of acid catalysts (8). 

Polypeptide Synthesis and Analysis. Sihca or controUed-pore glass supports treated with (chloromethyl)phenylethyltrimethoxysilane [68128-25-6] or its derivatives are replacing chloromethylated styrene—divinylbenzene (Merrifield resin) as supports in polypeptide synthesis. The sdylated support reacts with the triethyl ammonium salt of a protected amino acid. Once the initial amino acid residue has been coupled to the support, a variety of peptide synthesis methods can be used (34). At the completion of synthesis, the anchored peptide is separated from the support with hydrogen bromide in acetic acid (see Protein engineering Proteins). 

Etherification. The reaction of alkyl haUdes with sugar polyols in the presence of aqueous alkaline reagents generally results in partial etherification. Thus, a tetraaHyl ether is formed on reaction of D-mannitol with aHyl bromide in the presence of 20% sodium hydroxide at 75°C (124). Treatment of this partial ether with metallic sodium to form an alcoholate, followed by reaction with additional aHyl bromide, leads to hexaaHyl D-mannitol (125). Complete methylation of D-mannitol occurs, however, by the action of dimethyl sulfate and sodium hydroxide (126). A mixture of tetra- and pentabutyloxymethyl ethers of D-mannitol results from the action of butyl chloromethyl ether (127). Completely substituted trimethylsilyl derivatives of polyols, distillable in vacuo, are prepared by interaction with trim ethyl chi oro s il an e in the presence of pyridine (128). Hexavinylmannitol is obtained from D-mannitol and acetylene at 25.31 MPa (250 atm) and 160°C (129). 

Tin metal also reacts directly with a number of activated organic haUdes, including aHyl bromide, benzyl chloride, chloromethyl methyl ether, and P-halocarboxyhc esters and nitriles giving fair-to-good yields of diorganotin dihaUdes (97,111—114). 

The reactivity of the chloromethyl group is illustrated by the reaction of 2,5-dimethyl-3,4-dichloromethylthiophene (174) with water, which gives (175) Another example of ether formation, is the formation of (176) upon normal acidic workup of the reaction product from 2-thiophenemagnesium bromide and 2-thiophenaldehyde. With... 

An important side reaction is the formation of diaryl methane derivatives ArCHaAr. Moreover poly substituted products may be obtained as minor products. Aromatic compounds have been treated with formaldehyde and hydrogen bromide or hydrogen iodide instead of hydrogen chloride. The formaldehyde may be replaced by another aldehyde the term Blanc reaction however stands for the chloromethylation only. 

IV-chloromethyl-iV-methyl pyrrolidinium bromide (C-MEP) [48, 49, 75] /V-chloromethyl-/V-methyl morpholidinium bromide (C-MEM) [49] 2-Bromo-cyclohexylpyridinium bromide [50, 56, 63, 76]... 

Amyl bromide [Pentane, 1-bromo-], 82 Aniline [Benzenamine], 122 Anilines, o-alkylation of, 15 Anisole [Benzene, methoxy-], 48 Amsyl chloride [Benzene, l-(chloromethyl)-... 

Benzyl alcohol Hydrogen bromide, Iron l,2-Bis(chloromethyl)benzene Catalytic impurities See other gas evolution incidents, polycondensation reaction incidents... 

Bipyridine-centered triblock copolymers of the type BA-bpy-AB were prepared by a combination of ATRP and ROMP [159]. 4,4 -Bis(hydroxymelhyl)-2,2/-bipyridine was employed for the polymerization of lactic acid, LA or CL in the presence of Sn(Oct)2 in bulk at 130 and 110°C, respectively. The hydroxyl end groups were converted to tertiary or secondary bromo esters by reaction with 2-bromoisobutyryl bromide or 2-bromopropionyl bromide. The reaction yields were very high (> 80%) but not quantitative. These products were used as macroinitiators for the ATRP of MMA or tBuA in the presence of CuBr/HMTETA. 4,4/-bis(Chloromethyl)-2,2 -bipyridine was employed to promote the ATRP of MMA or styrene followed by the addition... 

In contrast, triphenylphosphine displaces bromide smoothly and the Wittig reaction then possible provides the recommended synthesis of 2-nitro-5-vinylfuran as sketched in scheme 35, B.192 Halomethylfurans and cyanide ion give nuclear substitution, as has long been known (Scheme 35, C). Nuclear substitutions occur for 2,5-bis(chloromethyl)furan,193 but are less... 

Benzyl bromide, Molecular sieve, 2735 Benzyl chloride, Catalytic impurities, 2738 1,2-Bis(chloromethyl)benzene, 2946 Bis(2-cyanoethyl)amine, 2397 Bis(trimethylsilyl) peroxomonosulfate, 2602 Borane -tetrahydrofuran, 0138 Butylmagnesium chloride, 1641 Calcium acetylide, Methanol, 0585 Calcium chloride, 3923 Cerium, Water, 3961... 

Acetyl-3-methyl-4,5-dihydrothiophen-4-one Benzyl alcohol, Hydrogen bromide, Iron Benzyl bromide, Molecular sieve Benzyl chloride, Catalytic impurities Benzyl fluoride l,2-Bis(chloromethyl)benzene Ethylene oxide, Contaminants Furoyl chloride... 

Powdered KOH (113 mg) is added to the aryl aldehyde (0.6 mmol), the chloromethyl-sulphone (0.5 mmol) and A-(4-trifluoromethyIbenzyl)quininium bromide (28 mg, 0.05 mmol) in PhMe (3 ml) at room temperature and the mixture is stirred for 2 h. Aqueous HCI (l M, 3 ml) is added to quench the reaction and the mixture is extracted with AcOEt (3 x 15 ml). The extracts are washed with brine (10 ml), dried (Na2S04), and evaporated to yield the chiral oxirane. 

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