Chloroform water

The potentiometric micro detection of all aminophenol isomers can be done by titration in two-phase chloroform-water medium (100), or by reaction with iodates or periodates, and the back-titration of excess unreacted compound using a silver amalgam and SCE electrode combination (101). Microamounts of 2-aminophenol can be detected by potentiometric titration with cupric ions using a copper-ion-selective electrode the 3- and... 

To a stirred solution of 2,3-dimethyl indole (6, 1.45 g, 10 mmol, 1.0 equiv) and tetra-n-butylammonium sulfate (3.40g, 10 mmol, 1.0 equiv) in chloroform (150 mL) was added potassium hydroxide (50% aqueous solution, 20 mL) over 30 minutes. The stirring was continued for six hours, at which time the mixture was extracted with chloroform, the chloroform-water mixture was washed with water, and the organic layer concentrated. Silica gel chromatography provided 2,4-dimethyl-3-chloroquinoline (7, 1.52 g, 79% yield). 

Betamethasone acetate is converted to betamethasone by means of hydrochloric acid in a methanol-chloroform-water mixture as described in U.S. Patent 3,164,618. 

Hok, B., Studies on the extraction of metal complexes. XV. The dissociation constants of salicylic acid, 3,5-dinitrobenzoic acid, and cinnamic acid and the distribution between chloroform-water and methyl isobutyl ketone (hexone)-water, Sv. Kem. Tidskr. 65, 182-194 (1953). 

See aryl chloroformates water See related ACYL halides... 

Cieplak, P., Caldwell, J. W., Kollman, P. A., Molecular mechanical models for organic and biological systems going beyond the atom centered two body additive approximation aqueous solution free energies of methanol and IV-methyl acetamide, nucleic acid base, and amide hydrogen bonding and chloroform/water partition coefficients of the nucleic acid bases, J. Comput. Chem. 2001, 22, 1048-1057... 

Paper chromatography has been used to separate and detect pseudoephedrine hydrochloride from other pharmacologically active amines. Whatman No. 1 paper developed in n-butanol water 95% acetic acid (4 5 1), n-butanol toluene water 95% acetic acid (10 10 5 5), ethyl acetate water 95% acetic acid (3 3 1), or chloroform water 95% acetic acid (10 5 4) gave Rf values of 0.73, 0.35, 0.57, and 0.52 for pseudoephedrine hydrochloride respectively. Visualization of pseudoephedrine hydrochloride was done by spraying the chromatogram with 0.5% bromcresol green in methanol or 0.2% nin-hydrin in acetic acid butanol 5 95.30... 

In order to construct the L-asparagine derivative of per-O-acetylated 0-(2-acetamido-2-deoxy-/ -D-glucopyranosyl( 1 — 4)-2-acetamido-2-deoxy-D-glucose (7), Spinola and Jeanloz (13) used (the sensitive) silver azide for conversion of the a-chloro anomer of the chitobiose derivative 8 into the / -azido derivative 9. Kunz and associates (14,15) have accomplished the conversion of the a-chloro anomer of 8 into 9 using sodium azide in the presence of tri-n-octyl-methylammonium chloride as a phase-transfer catalyst in chloroform water. 

Sodium alginate forms a raft on the stomach contents leading to a reduction in reflux. Aluminium is an insoluble salt that is used as an antacid with no particular advantage in reflux. Chloroform water is a traditional preparation to reduce colic. Sucrose and lactose are sugars with no effect on gastro-oesophageal reflux disease. 

B° (chlorofoi m 1 which was submitted to partial hydrolysis performed by one of the three following methods ( i) action of 1 3 acetic acid — water at room temperature (ii) addition of 1-5 mg of p-toluenesulfonlc acid to a stirred solution of in a 19 1 chloroform water (iii) adsorption of a solution of 4 (in a mixture of chloroform and water) onto a small column of silica gel for a few hours, followed by classical elution. In each experiment, a mixture of acetates S and 6 (ratio 65 35) was obtained quantitatiuely. These deriuatiues having respectively OH-4 or OH-6 free were separated in high yield. 

Finally, partial hydrolysis of compound 27 (adsorption of a solution in chloroform—water onto a column of silica-gel and standard elution) gave regiospecifi-cally the acetate 28 I yield 60%, plus recovery of 10% of starting naterial, m.p. 03 — 04 - C, [ a] +56 (chloroform)] with OH—2 free. This orientation was not affected if we started from samples of compound 2 containing different proportions of diastereoisomers. 

Table 11.3 Absolute free energies of solvation (kcal mol ) and chloroform/water partition coefficients (logio units) for nucleic acid bases at the SM5.4/AM1 Icvcf ...

The similar accuracies of different well-parameterized continuum models implies that they will also perform similarly for the computation of partition coefficients, and that has proven to be the case in most studies to date (see, for example, Bordner, Cavasotto, and Abagyan 2002 and Curutchet et al. 2003b). In Table 11.4 the previously presented SMx results for the chloroform/water partitioning of die methylated canonical nucleic acid bases are compared to results from die MST-ST/HF/6-31G method, and also to purely electrostatic results obtained using a multipole expansion SCRF method. As the latter does not include any accounting for non-electrostatic effects, its performance is significantly degraded compared to the other two. 

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