Chloro cyclohexane

The semi-empirical CNDO/2 approximation has been used in an extended treatment of intramolecular interactions in 2-fluoro- and 2-chloro-cyclohexanes. The calculations are analysed in terms of orbital interactions and partition of the total energy. 

Cyclohexene Methanol Methyl 2-chloro-cyclohexane carboxylate-1 36... 

Cyclohexadienones, substituted, preparation of, 46,119 reactions of, 46,119 Cyclohexane from reduction of chloro-cyclohexane, 47,105 A -o-Cyclohexaneacetic acid, ethyl ESTER, 45, 44... 

It is believed that equatorial substituents such as chlorine or bromine would increase the guest diameter beyond the allowed values (assuming that the guest molecules stack roughly parallel to the canal68)). Support for this comes from the study of fluorocyclohexane where the population of the axial conformer is not enhanced to any major extent70. Nitro-71) and cyano-cyclohexane, trans-l,2-dichloro-, trans-1,2-dibromo-, tram-1,4-dichloro-, trans-1,4-dibromo-, and trans-l-bromo-4-chloro-cyclohexane all pack most efficiently in the thiourea canals as the axial or diaxial conformer 68,72. Tram-2,3-dichloro-1,4-dioxane behaves similarly73. In contrast isocyanato-, tram-1,4-diiodo-, trans-1 -bromo-4-iodo-, and tram-1 -chloro-4-iodo-cyclohexane are present as mixtures of the axial/equatorial or diaxial/diequatorial conformations as appropriate 68,72). The reason for this anomalous behaviour of the iodosubstituted cyclohexanes is not clear. 

Preparation 316.—Menthyl Chloride (1-Methyl-i-isopropyl-Z-chloro-cyclohexane). 

Photolysis of CsFsSCl in cyclohexane leads to formation of both arylthio- and chloro-cyclohexane by a radical pathway.Sulfiiryl chloride in pyridine can chlorosulfonate alkanes by a radi( route under photolytic conditions, the chloride being a minor product (equation 68).SO2 and Ch also gives the sulfonyl chloride by the route shown in equations (69) to (72). ... 

W. Kramer, K. Ballschmiter, Global baseline pollution studies, XII. Content and pattern poly-chloro-cyclohexane (HCH) and -biphenyls (PCB), and content of hexachlorobenzene in the water column of the Atlanctic Ocean, Fresenius J. Anal. Chem., 330 (1988), 524-526. 

F nre 10 Theoretical and experimental [Pg.31]

There are two stereoisomers of 1-tert-butyl-4-chloro-cyclohexane. One of these isomers reacts with sodium ethoxide in an E2 reaction that is 500 times faster than the reaction of the other isomer. Identify the isomer that reacts faster, and explain the difference in rate for these two isomers. 

TheTnain products of the radiolysis of methanesulfonyl chloride solutions in cyclohexane are methane, and chloro-cyclohexane. In addition, small amounts of methylchloride are also formed. The yields of these products satisfy the material balance relations XI and XII. 

A second class of herbicides primarily affects ( -carotene desaturase. These herbicides are apparent feedback inhibitors of PD as well. This class of compounds includes dihydropyrones like LS 80707 [90936-96-2] (56) and 6-methylpyridines (57,58). The third class consists of the ben2oylcyclohexane-diones, eg, 2-(4-chloro-2-nitroben2oyl)-5,5-dimethyl-cyclohexane-I,3-dione. This class of atypical bleaching herbicides induces phytoene accumulation when appHed either pre- or post-emergence. However, it does not inhibit phytoene desaturase activity in vitro (59). Amitrole also has been considered a bleaching herbicide, though its main mode of action is inhibition of amino acid synthesis. 

C. It can be obtained from its hahde-free solutions in cyclohexane and ethylether by vacuum distUlation to remove the ether. The usual preparative method is by reaction of chloro- or bromobenzene and lithium metal in ethyl ether or in a mixture of ethyl ether and cyclohexane. 

Medium Boiling Esters. Esterificatioa of ethyl and propyl alcohols, ethylene glycol, and glycerol with various acids, eg, chloro- or bromoacetic, or pymvic, by the use of a third component such as bensene, toluene, hexane, cyclohexane, or carbon tetrachloride to remove the water produced is quite common. Bensene has been used as a co-solvent ia the preparatioa of methyl pymvate from pymvic acid (101). The preparatioa of ethyl lactate is described as an example of the general procedure (102). A mixture of 1 mol 80% lactic acid and 2.3 mol 95% ethyl alcohol is added to a volume of benzene equal to half that of the alcohol (ca 43 mL), and the resulting mixture is refluxed for several hours. When distilled, the overhead condensate separates iato layers. The lower layer is extracted to recover the benzene and alcohol, and the water is discarded. The upper layer is returned to the column for reflux. After all the water is removed from the reaction mixture, the excess of alcohol and benzene is removed by distillation, and the ester is fractionated to isolate the pure ester. 

Terephthalic acid has been obtained from a great many /)-disubstituted derivatives of benzene or cyclohexane by oxidation with permanganate, chromic acid, or nitric acid. The following routes appear to have preparative value from />-toluic acid, />-methylacetophenone,2 or dihydro-/)-tolualdehyde by oxidation with permanganate from f>-cymene by oxidation with sodium dichromate and sulfuric acid from />-dibromobenzene or from /i-chloro- or -bromobenzoic acid by heating at 250° with potassium and cuprous cyanides and from />-dibromo-benzene, butyllithium, and carbon dioxide. ... 

A solution of 0.7 g of 2-(2-amino-N-methylacetamido)-5-chlorobenzophenone in 10 ml of a 50% solution (by weight) of diketene in acetone is refluxed for 3 hours and then evaporated to give a brown oil. The oil Is chromatographed on 200 g of silica gel using a 1 1 (by volume) mixture of ethyl acetate cyclohexane 25 ml fractions are collected. Fractions 11-14 are combined, mixed with chloroform, evaporated and triturated with ether to give 0.337 g of 11-chloro-8,12b-dihydro-2,8-dimethy 1-12b-phenyl-4H-[ 1,3]oxazino[3,2-dl [1,4] benzodiazepine-4,7 (6H)-dione as a pale yellow solid, MP 174°C to 176°C. 

A) 1-(2-Amino-5-chlorophenyll-1-(2-fluorophenyll-2-a2a-but-1-en-4-ol A mixture of 40 g of 2-methylimidazole hydrochloride and of 90 g of 2-amino-5-chloro-2 -fluoro-benzophenone in 240 ml of ethanolamine is heated at 135 for 2 hours. After cooling, the reaction mixture is poured into an aqueous sodium bicarbonate solution. The mixture is extracted with ether, the organic phase is washed repeatedly with water and is dried over sodium sulfate, and the solvent is evaporated to dryness. The residual oil is chromatographed on a silica column, elution being carried out with a 50/50 mixture of cyclohexane and ethyl acetate. 

Sodium methoxide (1.2 g) in dimethylformamide (150 ml) was stirred with 3,5-dim ethoxy-4 reaction mixture was then treated with /3-morpholinoethyl chloride (3.4 g) and heated for 1 hour at 140°C, then evaporated to dryness, and treated with water to give a solid material. The mixture was filtered, washed and crystallized from cyclohexane to give 3,5-di-methoxv-4 -chloro-4-( morpholinoethoxy)-benzophenone (6.5 g), MP 91°C to 92°C. The product was then reacted at about 0°C with gaseous hydrogen chloride in ether to give, after crystallization from isopropanol, the corresponding hydrochloride which hada MPof 187.9°C. 

A mixture of 4,4 parts of 1-chloro-3-(1-naphthoxy)-2-propano and 16 parts of isopropylamine is heated in a sealed vessel at 70° B0°C for 10 hours. The vessel is cooled and to the contents there are added 50 parts of water. The mixture is acidified with 2N hydrochloric acid, and washed with 50 parts of ether. The aqueous phase Is decolorized with carbon, and then added to 50 parts of 2N sodium hydroxide solution at 0°C, The mixture is filtered. The solid residue is washed with water, dried, and crystallized from cyclohexane. There is thus obtained 1-isopropylamino-3-(1-naphthoxy)-2-propanol, MP 96°C. 

Chloro-2,4-dimethyl-cyclohexane (less stable chair form)... 

A 7-chloro-5-phenyl-l//-l,3,4-benzotriazepine-2(3//)-thione24 (2.5 mmol) in dioxane (l 5 mL) was treated with powdered Pb(OAc)2 (1.63 g. 5 mmol) and an amine was passed for 30 min into the suspension. The mixture was left for a specified time. H,S was passed through the mixture and the precipitated lead sulfide was filtered off. The filtrate was evaporated in a stream of air to leave the product, which was recrystallized (cyclohexane). 

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