2-Chloro-4-amino benzoic acid

Chloro-4-amino benzoic acid (3-Diethyl amino ethanol... 

Chemical Name 5-(aminosulfonvl)-4-chloro-2-[(2-furanylmethvl)amino] benzoic acid Common Name —... 

Chemical Name 2-[(7-Chloro-4-quinolinyl)amino] benzoic acid 2 3-dihydroxy-propyl ester Common Name Glycerylaminophenaquine Structural Formula ... 

Benzoic acid,4-amino-3-[(methylthio)-methyl] -, ethyl ester, 15 Benzoic acid, 2-benzoyl-, methyl ester, 63 Benzoic acid, 4-bromo-, 86 Benzoic acid, 4-chloro-, 86 Benzoic acid, 2,4-dimethoxy-, 31 Benzoic acid, 3,4-dnnethoxy-, 31 Benzoic acid, 3,4-dimethyl-, 31 Benzoic acid, 3,5-dimethyl-, 86 Benzoic acid, 4-hydroxy-, 60 Benzoic acid, 2,4,6-tnmethyl-, 31 methyl ester, 63... 

CN 2-t(7-chloro-4-quinolinyl)amino]benzoic acid 2,3-dihydroxypropyl ester... 

AMINOSULFURANYL)-4-CHLORO-2-((2-FURNAYLMETHYL)AMINO)BENZOIC ACID see CHJ7S0... 

The lead compound in the discovery of diuretics was sulfanilamide. An important product was chlorothiazide (157) (Scheme 33), which became the model for the most important thiazide diuretic, furosemide, or frusemide, 4-chloro-A-furfuryl-5-sulfamoylanthranilic acid, or 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)amino] benzoic acid (158), used... 

The relative p a values depend on the substituent. For chloro-substituted benzoic acids, the ortho isomer is the most acidic and the para isomer is the least acidic for nitro-substituted benzoic acids, the ortho isomer is the most acidic and the meta isomer is the least acidic and for amino-substituted benzoic acids, the meta isomer is the most acidic and the ortho isomer is the least acidic. Explain these relative acidities. 

The exact mechanism of action of the -amino levulinic acid synthetase is not clear. It involves the activation of glycine by pyridoxal phosphate in a Schiff base formation on the enzyme. A proton is lost in the process, and a stable carbanion is formed. In the presence of succinyl CoA, the activated glycine is transferred to succinate, but it is not clear whether the decarboxylation occurs while the succinate and glycine are still attached to the enzyme or later. The activity of the -amino levulinic acid synthetase is inhibited by L-penicillamine, thiosolidine, and L-cysteine. The compounds presumably react with pyridoxal phosphate forming a thiazolidine ring. The enzyme molecule is itself inhibited by the addition of para-chloro-mercuri-benzoic acid. Insofar as succinate is a precursor of 5-amino levulinic acid, the pathway for succinyl CoA synthesis acquires particular significance (refer to the first part of this book). In the reticulocyte, the tricar-... 

Furosemide 5-(Aminosulfonyl)-4-chloro-2[2-(furanylmethyl)amino]benzoic acid... 

N-(3-chloroaUyl)-hexaminium chloride cloruro de N-(3-cloralil)hexaminio chloroaluminium diisopropoxide diisopropoxido de cloraluminio chloroamine cloramina 2-chloro-5-amino-benzoic acid acido 2-cloro-5-aminobenzoico p-chloro-o-aminophenol p-cloro-o-aminofenol 2-chloro-4-tert-amylphenol 2-cloro-4-terc-amilfenol m-chloroaniline m-cloranilina o-chloroaniline o-cloranilina 4-chloroaniline-3-sulfonic acid acido 4-cloranilina-3-sulfonico... 

The phototoxic diuretic drug furosemide 6, a 5-(aminosulfonyl)-4-chloro-2-[(2-furanylmethyl)-amino] benzoic acid, is photolabile under aerobic and anaerobic conditions. Previous studies have established that furosemide causes adverse photosensitizing effects in vivo and has a high in vitro photosensitizing capability. In this context, it is capable of initiating both energy transfer and free radical reactions. Irradiation of a methanol solution of 6 produces under an oxygen atmosphere photoproducts... 

Chlotobenzoyl)-benzoic acid is nitrated in concentrated sulfuric acid, then reduction of the nitro group, ring closure, and hydrolysis occur simultaneously in concentrated sulfuric acid in the presence of a reducing agent and boric acid. Thus obtained cmde chloro pink is purified by selective precipitation from sulfuric acid in order to separate it from by-produced 2-amino-3-chloto-l-hydroxyanthtaquinone (24) (36). 

Indapamide Indapamide, 4-chloro-N-(2-methyl-l-indolinyl)-3-sulfamoylbenzamide (21.3.33), is synthesized from 2-methylendoline, the nitrosation of which gives 2-methyl-1-nitrosoindoline (21.3.31). Reducing this with lithium aluminum hydride leads to formation of l-amino-2-methylendoline (21.3.32). Acylating this with 3-sulfonylamino-4-chlor-benzoic acid chloride leads to (21.3.33) [53,54]. 

Dinitro-diphenylamin)-<3 azo-3> (2 .4 -dinitro-diphenylamin) in Ger], [(02N)2CgH3-NH.CgH4.N. ]2 mw 544.43, N 20.58% golden-yel ndls(from pyridine), mp 285° sol in hot pyridine and in benzoic acid ethylester insol in other solvs was prepd by the condensation of 3"amino -3 -(2,4-dinitroanilino)-azobenzene with 4-chloro -1,3-dinxtrobenzene... 

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