1- -hexaminium chloride

Formaldthyde Arylsulfonamide resin, chloroallyl-hexaminium chloride... 

Chlorinated rubber. See Rubber, chlorinated N-(3-Chloroallyl) hexaminium chloride 1-(3-ChloroallyD-3,5,7-triaza-1-azoniaadamantane chloride. See Quaternium-15 Chloroalonil. See Tetrachloroisophthalonitrile... 

N-(3-chloroallyl) hexa-methylenetetraminium-chloride, (the cis-isomer of this substance) Chloroallylhexaminium chloride, 3-chloroallyl hexaminium chloride, Dowicil 75, Dowicil 200, Quaternium 15 42 53... 

Synonyms azoniaadamantane chloride chloroallyl methanamine chloride cis-i-(3-chloroallyl)3,5,7-triaza-i-azoniaadamantane chloride Dowicil 75, 100, 200 (chemically similar) Dowicil 200 methanamine-3-chloroallylochloride N-(3-chloroallyl) hexaminium chloride Preventol Di chloro-2-propenyl-3,5,7-triaza-i-azoniatricyclo[3.3.i.i(3,7)]decane chloride Dowicil 150 hexamethylenetetramine... 

Table 24. Minimum Inhibition Concentrations (MIC) of iV-(3-chloroallyl)-hexaminium Chloride in Nutrient Agar and Minimum Lethal Concentrations (MLC) Determined through a Tube Suspension/Dilution Technique (Exposure Time 48 h)...

The efficacy of iV-(3-chloroallyl)-hexaminium chloride covers a broad spectrum of bacteria and mould producing fungi, yeasts included. However, the activity against bacteria is more pronounced than that against fungi, characterizing the microbicide as a formaldehyde releasing compound. 

A -(3-chloroallyl)-hexaminium chloride is listed in the EC list of preservatives for cosmetics with a maximum addition rate of 0-2%. 

Table 27. Minimum Inhibition Concentrations (MIC) of iV-carbamoyl-hexaminium Chloride in Nutrient Agar...

EEC-no. 31 approval for antimicrobial applications N-(3-chloroallyl)-hexaminium-chloride, Quatemium-15 DOW... 

Table 26 Minimum inhibition concentrations (MIC) of N-(3-chlorallyl)-hexaminium chloride (67.5%). in nutrient agar (Source Dow Chemical Co.)...

N-(N -hydroxymethyl-)carbamoylmethyl-hexaminium chloride is compared with other quaternary hexaminium salts of superior efficacy as the starting material for quaternizing hexamethylenetetramine in this case is a formaldehyde releasing compound, too, namely N-hydroxymethyl-chloracetamide (3.4.1.) - Applications as described under 3.3.2. - 3.3.4. - Addition rates 0.05-0.2%. 

N-(3-chloroaUyl)-hexaminium chloride cloruro de N-(3-cloralil)hexaminio chloroaluminium diisopropoxide diisopropoxido de cloraluminio chloroamine cloramina 2-chloro-5-amino-benzoic acid acido 2-cloro-5-aminobenzoico p-chloro-o-aminophenol p-cloro-o-aminofenol 2-chloro-4-tert-amylphenol 2-cloro-4-terc-amilfenol m-chloroaniline m-cloranilina o-chloroaniline o-cloranilina 4-chloroaniline-3-sulfonic acid acido 4-cloranilina-3-sulfonico... 

Cognate preparations. p-Nitrobenzaldehyde. This preparation is an example of the Sommelet reaction in which the hexaminium salt is isolated. Dissolve llg (0.13mol) of hexamethylenetetramine in 70ml of chloroform (CAUTION) and add 11.4 g (0.067 mol) of p-nitrobenzyl chloride or 14.4 g of p-nitrobenzyl bromide (Expt 6.28). Heat the mixture under reflux on a steam bath for 4 hours a precipitate gradually separates. Replace the reflux condenser by a condenser set for distillation and distil off about 35 ml of solvent. Add 35 ml of acetone, cool in ice, collect the precipitate by suction filtration and dry it in the air. Heat the hexaminium salt thus obtained under reflux for 1 hour with 100 ml of 50 per cent acetic acid then add 100 ml of water and 25 ml of concentrated hydrochloric acid and continue the refluxing for 5-10 minutes. Cool the solution in ice, collect the crystals of p-nitrobenzaldehyde and dry them in a vacuum desiccator. The yield is 6.4 g (63%), m.p. 106 °C. The p.m.r. spectrum is noted in Expt 6.117. 

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