Chest pressure sensation

The most frequently reported adverse events are headache, polycythemia, tiredness, common cold, diarrhea, nausea, stomach pains, chest pressure sensation, back pain, leg pain, and dizziness, as confirmed in a phase I open bioequivalence parallel group study of two recombinant human epoetin alfa products the pattern of the adverse events revealed no relevant differences between the erythropoietin derivatives [95 ]. Patients who were randomized to early intervention with immediate epoetin alfa (n = 68) or to standard intervention with epoetin alfa (n = 68), and a further 50 who were not randomized, pain, injection-site pain, bone pain, and deep vein thrombosis were observed [96 ]. 

Supraventricular tachycardias may cause a variety of clinical manifestations ranging from no symptoms to minor palpitations and/or irregular pulse to severe and even life-threatening symptoms. Patients may experience dizziness or acute syncopal episodes symptoms of HF anginal chest pain or, more often, a choking or pressure sensation during the tachycardia episode. 

Peripheral or sensory neuropathy (usually occurs in hands, feet, perioral area, and throat but may present as jaw spasm, abnormal tongue sensation, eye pain, chest pressure, or difficulty walking, swallowing, orwriting), nausea (64%), fatigue, diarrhea, vomiting, constipation, abdominal pain, fever, anorexia Occasional (14%-10%)... 

Oral Warm or hot sensation, asthenia, chest pressure... 

Adverse effects. General reactions include headache, dizziness, nausea, vomiting, disorientation, pressure sensations in the chest, myalgia, hypotension, a metallic taste, urticaria and hypersensitivity. Intravenous iron may rarely cause anaphylactoid reactions and facilities for cardiopulmonary resuscitation should be available. 

Patients frequently complain of intermittent episodes of rapid heart rate/palpitations that start and stop abruptly, usually without provocation (but occasionally during exercise). Severe symptoms include syncope. Often (in particular, those with AV nodal reentry) patients complain of a chest pressure or a fullness in the neck sensation. This is due to simultaneous AV contraction with the right atrium contracting against a closed tricuspid valve. Life-threatening symptoms (syncope, hemodynamic collapse) are associated with extremely rapid rate (e.g., >200 beats per minute) and atrial fibrillation associated with an accessory AV pathway. 

A 41-year-old physician accidentally injected adrenaline into his thumb and developed lightheadedness, sweating, tachycardia, and a sensation of chest pressure, which lasted about 2 minutes. The thumb became swollen and painful and then pale and cold it responded to warming and there was full recovery after 4 hours. 

Cardiac and respiratory conditions most likely will benefit from this form of treatment However, care must be taken to develop interventions that facilitate improvement without compromising other considerations. Thoracic pumping may increase respiratory capacity and fluid dynamics, but to one experiencing the sensation of extreme chest pressure, the benefits may be outweighed by the psychological considerations. As in all cases of manipulative or other interventions, decisions are best developed when a diagnosis is made and indications and contraindications are evaluated. 

Patients typically describe pain as a sensation of pressure, heaviness, or squeezing in the anterior chest area. Sharp pain is not a typical symptom of IHD. 

Symptoms may include a sensation of pressure or burning over the sternum or near it, which often radiates to the left jaw, shoulder, and arm. Chest tightness and shortness of breath may also occur. The sensation usually lasts from 30 seconds to 30 minutes. 

Side effects of triptans include paresthesias, fatigue, dizziness, flushing, warm sensations, and somnolence. Minor injection site reactions are reported with SC use, and taste perversion and nasal discomfort may occur with intranasal administration. Up to 15% of patients report chest tightness, pressure, heaviness, or pain in the chest, neck, or throat. Although the mechanism of these symptoms is unknown, a cardiac source is unlikely in most patients. Isolated cases of myocardial infarction and coronary vasospasm with ischemia have been reported. 

Adverse reactions occurring in 3% or more of patients include the following asthenia, chest pain/pressure, dizziness, drowsiness, dry mouth, dyspepsia, fatigue, headache, heaviness, miscellaneous CNS effects, miscellaneous sensations, myasthenia, nausea, neck/throat/jaw pain/pressure, pain in specified/unspecified locations, paresthesia, skeletal pain/pressure, somnolence, vertigo, warm/cold sensation, warm/hot sensation. 

Adverse effects include increased blood pressure, burning sensation in lips, mouth and throat nausea, vomiting, sweating, pain in chest, throat or hands painful sterile abscess at site of injection haemolytic anaemia in patients with G-6-PD enzyme deficiency hypertension, tachycardia, salivation, lacrimation and conjunctivitis. 

ALMOTRIPTAN, ELETRIPTAN MACROLIDES -CLARITHROMYCIN, ERYTHROMYCIN, TELITHROMYCIN t plasma concentrations of almotriptan and eletriptan, with risk of toxic effects, e.g. flushing, sensations of tingling, heat, heaviness, pressure or tightness of any part of body including the throat and chest, dizziness Almotriptan is metabolized mainly by CYP3A4 isoenzymes. Most CYP isoenzymes are inhibited by clarithromycin to varying degrees, and since there is an alternative pathway of metabolism by MAO-A, toxicity responses will vary between individuals Avoid co-administration... 

---