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Alkylating Chemotherapeutic Agents

Leukemia Benzene, ionizing radiation, chemotherapeutic alkylating agents... [Pg.243]

Chemotherapeutic agents are grouped by cytotoxic mechanism. The alkylating agents, such as cyclophosphamide [50-18-0] and melphalan [148-82-3] interfere with normal cellular activity by alkylation deoxyribonucleic acid (DNA). Antimetabohtes, interfering with complex metaboHc pathways in the cell, include methotrexate [59-05-2] 5-fluorouracil [51-21-8] and cytosine arabinoside hydrochloride [69-74-9]. Antibiotics such as bleomycin [11056-06-7] and doxombicin [23214-92-8] h.a.ve been used, as have the plant alkaloids vincristine [57-22-7] and vinblastine [865-21-4]. [Pg.406]

The antineo plastic chemotherapeutic agent that is classified as an alkylating agent is... [Pg.87]

The answer is b. (Hardmanr p 1241.) Busulfan is an alkylating agent that, in contrast to other alkylators, is an alkylsulfonate. Thioguanine is a purine antimetabolite. Bleomycin is classified as a chemotherapeutic... [Pg.94]

Anticancer drugs act on cells in active proliferation and may interfere with a specific phase of the cell cycle or act independently from it. Some of these drugs are naturally occurring compounds, identified in plants or microorganisms, some are synthetic chemicals. Among the major classes of chemotherapeutics include antimetabolites, alkylating agents, inhibitors of the... [Pg.91]

It is also alkylating agent and inhibits DNA synthesis. It is administered intravenously in combinations with other chemotherapeutic drugs for treating carcinomas of the pancreas, breast, lungs, prostate, head, neck, and so on. Synonyms of this drug are ametycin and others. [Pg.405]

BASIC PHARMACOLOGY OF CANCER CHEMOTHERAPEUTIC DRUGS Alkylating Agents... [Pg.1165]

Chemotherapeutic agents, useful in me treatment of neoplastic diseases, exert their therapeutic effects by modifying me synthesis or functions of nucleic acids (see Chapter 51 and Chapter 58). For example, 6-mercaptopurine inhibits purine-ring biosynthesis, cytarabine inhibits DNA polymerase, alkylating agents crosslink DNA, and hydroxyurea inhibits the conversion of ribonucleotides into deoxyribonucleotides. However, other pharmacologic agents such as chlorpromazine, a... [Pg.28]

Patenaude A, Deschesnes RG et al (2007) New soft alkylating agents with enhanced cytotoxicity against cancer cells resistant to chemotherapeutics and hypoxia. Cancer Res 67 2306-2316... [Pg.23]

Cyclophosphamide, a nitrogen mustard alkylating agent, is a widely used cancer chemotherapeutic drug to treat lymphomas, leukemias, multiple myeloma and a numerous solid tumors. Cyclophosphamide can induce nephrotoxicity characterized as decreased water excretion and an inappropriate concentration of urine. These effects are due to a direct effect of one or more alkylating cyclophosphamide metabolites at distal tubules and collecting ducts. Special caution is warranted to avoid water-induced diuresis or diuretic therapy in these patients as hyponatremia can become a problem. [Pg.1488]

Chemical/Pharmaceutical/Other Class Alkylating agent DNA alkylating agent Chemotherapeutic agent... [Pg.1684]

See other pages where Alkylating Chemotherapeutic Agents is mentioned: [Pg.25]    [Pg.25]    [Pg.462]    [Pg.463]    [Pg.173]    [Pg.25]    [Pg.25]    [Pg.462]    [Pg.463]    [Pg.173]    [Pg.302]    [Pg.445]    [Pg.12]    [Pg.100]    [Pg.548]    [Pg.100]    [Pg.347]    [Pg.518]    [Pg.91]    [Pg.171]    [Pg.126]    [Pg.302]    [Pg.118]    [Pg.1312]    [Pg.1315]    [Pg.117]    [Pg.120]    [Pg.252]    [Pg.858]    [Pg.174]    [Pg.300]    [Pg.814]    [Pg.12]    [Pg.400]    [Pg.205]    [Pg.350]    [Pg.1488]    [Pg.150]   
See also in sourсe #XX -- [ Pg.170 ]



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