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Cancer chemotherapeutic drugs

Zhang C. Genetic susceptibility to microtubule-active cancer chemotherapeutic drugs p53 action and the role of MAP4. Proceedings ofAACR 1998 1308. [Pg.250]

BASIC PHARMACOLOGY OF CANCER CHEMOTHERAPEUTIC DRUGS Alkylating Agents... [Pg.1165]

The dihydrotriazines are of interest because of their antimalarial activity, and their potential as cancer chemotherapeutic drugs (see Section 2.20.5.10). The X-ray crystallographic analysis of the antimalarial drug cycloguanil (12) (as the hydrochloride salt) has... [Pg.461]

Figure 22.13. Structures of nitrogen mustards used as cancer chemotherapeutic drugs. Figure 22.13. Structures of nitrogen mustards used as cancer chemotherapeutic drugs.
Title Melphalan Derivatives and Their Use as Cancer Chemotherapeutic Drugs... [Pg.525]

Table 4 Cancer chemotherapeutic drugs capable of inducing nephrotoxicity... Table 4 Cancer chemotherapeutic drugs capable of inducing nephrotoxicity...
Cyclophosphamide, a nitrogen mustard alkylating agent, is a widely used cancer chemotherapeutic drug to treat lymphomas, leukemias, multiple myeloma and a numerous solid tumors. Cyclophosphamide can induce nephrotoxicity characterized as decreased water excretion and an inappropriate concentration of urine. These effects are due to a direct effect of one or more alkylating cyclophosphamide metabolites at distal tubules and collecting ducts. Special caution is warranted to avoid water-induced diuresis or diuretic therapy in these patients as hyponatremia can become a problem. [Pg.1488]

Antibiotics The clinical use of three antibiotic cancer chemotherapeutic drugs (mitomycin C, mi-thramycin, and doxorubicin) has been associated with the development of nephrotoxicity. Each of these drugs is commonly used in combination chemotherapy which in some cases might result in additive or enhanced nephrotoxicity. [Pg.1489]

As an example of the application of this methodology. Dedrlck and his associates examined the pharmacokinetics of the cancer chemotherapeutic drug, methotrexate ( 12). This... [Pg.27]

Schein, P. S., and T. Anderson. 1973. The efficacy of animal studies in predicting clinical toxicity of cancer chemotherapeutic drugs. International Journal of Clinical Pharmacology 8 22-38. [Pg.310]

Their persistence occurs because telomerase is constitutively active in cancer cells. This means that telomerase is an attractive target for the development of new cancer chemotherapeutic drugs. [Pg.258]

Some cancer chemotherapeutic drugs are carcinogenic and/or mutagenic. They are widely used in hospital and laboratories, and there is a widespread demand for methods for their safe disposal and for surface decontamination, a field completely neglected. Research was therefore initiated on a number of these compounds doxorubicin, daunorubicin, methotrexate, dichlorom-ethotrexate, cyclophosphamide, ifosfamide, vincristine sulfate, vinblastine sulfate, 6-thioguanine, 6-mer-captopurine, cisplatin, lomustine, chlorozotocin, streptozotocin, carmustine, semustine, PCNU and melphalan. [Pg.64]

The following outline of advances appearing in the literature over the three-month period August-November 1977 provides an illustration of current efforts to discover new higher and lower plant cancer chemotherapeutic drugs. In 1973, we reported the first pseudoguaianolide-type sesquiterpene to display in vivo antineoplastic activity. ° At that time, we found the sesquiterpene lactone helenalin to be quite active against the... [Pg.6]

Crounse RG, Van Scott EJ (i960) Changes in scalp hair roots as a measure of toxicity from cancer chemotherapeutic drugs. J Invest Dermatol 35 83-84... [Pg.272]

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See also in sourсe #XX -- [ Pg.52 ]

See also in sourсe #XX -- [ Pg.52 ]

See also in sourсe #XX -- [ Pg.169 ]



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