Chemokine interactions

Table 7.1 Proteolytic processing of chemokines interacting with described HIV coreceptor...

Despite the extensive studies performed to elucidate the biological effects of the receptor/chemokine interaction, the intracellular biochemical pathways required to achieve such a variety of biological effects remain to be further elucidated. 

Opioid-Chemokine Interactions 16.2.1 Chemokine Ligands and Receptors... 

Considerable evidence for opioid-chemokine interactions comes from studies of pain and inflammation, where the inherent relationships between pain, inflammation, and the counteracting antinociceptive influences of opioids have considerable biomedical implications. The adaptive changes in immune and nervous system function with chronic inflammation and pain further reveal the inherent interrelatedness between opioids (Ossipov et al. 2003 Evans 2004 Roy et al. 2006 Christie 2008)... 

Figure 4.1. Schematic representation of leukocyte transmigration induced by chemokines. The first step involves rolling attributed to interaction between the leukocyte and the endothelial cells. This process is mediated by selectins and selectin ligands expressed on the surface of both cell types. In the next step a chemokine interacts with its receptor, inducing leukocyte activation and conformational changes in the adhesion molecules (integrins) and resulting in firm adhesion to the endothelial surface. It is believed that the chemokine is immobilized on the endothelial surface by interactions with glycosaminoglycans. The leukocytes then transmigrate into the tissues.

Rot, A. (2003). In situ binding assay for studying chemokine interactions with endothelial cells. J Immunol Methods 273(1-2) 63-71. 

Preincubation of I-CCL3 with various concentrations of the GAGs heparin and heparan sulphate, up to 100 pg/ml, prior to binding to the W Lister vCKBP-2 revealed that GAGs did not interfere with the vCKBP-chemokine interaction. In contrast, pretreatment of human... 

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