Dysidea frondosa

Frondosins A E (Figure 5.7) are a family of five norsesquiterpenoid (14-earbon) natural produets that were originally extracted from the marine sponge Dysidea frondosa and later isolated from the HIV-inhibitory extract of Euryspongia sp. These compounds have shown IL-8a, IL-8p, protein kinase C (PKQ activities and anti-HTV activity. Trost et al. first achieved the total synthesis of frondosin... 

Patil AD, Freyer AJ, Killmer L, Offen P, Carte B, Jurewicz AJ, Johnson RK (1997) Frondosins, Five New Sesquiterpene Hydroquinone Derivatives with Novel Skeletons from the Sponge Dysidea frondosa Inhibitors of Interleukin-8 Receptors. Tetrahedron 53 5047... 

Frondosin B 160 (Figure 19.16) is a sesquiterpene that was isolated from the marine sponge Dysidea frondosa in 1997 [80]. This compound exhibits low micromolar inhibitory activity against the inflammatory chemokine interleukin-... 

Patil. A.D.. Freyer, A.J., KiDmer, A.J., Offen, P., Carte, B., Jurewicz, A. J., and Johnson, R.K (1997c) Frondosins, frve new sesquiterpene hydroquinone derivatives with novel skeletons from the sponge Dysidea frondosa. Tetrahedron, 53, 5047—5060. 

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