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Chemokine-mediated migration

Inhibitors of chemokine receptors are not only potential therapeutics against inflammatory diseases, but also cancer therapeutics. Recently, several studies reported that many cancer cell lines possess a high metastatic index via chemokine-mediated migration [20,21]. [Pg.177]

Shields, J. D., M. S. Emmett, D. B. Dunn, K. D. Joory, L. M. Sage, H. Rigby, P. S. Mortimer, A. Orlando, J. R. Levick, and D. O. Bates. 2007. Chemokine-mediated migration of melanoma cells towards lymphatics-a mechanism contributing to metastasis. Oncogene 26 2997-3005. [Pg.107]

The Role of Chemokine and Glycosaminoglycan Interaction in Chemokine-Mediated Migration In Vitro and In Vivo... [Pg.309]

Fischer AM, Mercer JC, Iyer A, Ragin MJ, August A. Regulation of CXC chemokine receptor 4-mediated migration by the Tec family tyrosine kinase ITK. J Biol Chem 2004 279(28) 29816-20. [Pg.70]

Chemokine-mediated DC migration determines disease outcome. In the future, steady-state migration and more complicated migration within effector sites (LNs) will be clarified also by chemokine research. Such studies would provide novel therapeutic strategies against various immune diseases. [Pg.98]

Garcia-Vicuna R, Gomez-Gaviro MV, Dominguez-Luis MJ, et al. CC and CXC chemokine receptors mediate migration, proliferation, and matrix... [Pg.195]

Vande Broek I, Asosingh K, Vanderkerken K, et al. Chemokine receptor CCR2 is expressed by human multiple myeloma cells and mediates migration to bone marrow stromal cell-produced monocyte chemotactic proteins MCP-1, -2, and -3. Br J Cancer 2003 88 855-862. [Pg.350]

Gunn, M.D., Chemokine mediated control of dendritic cell migration and function, Semin. Immunol. 15, 5, 271, 2003. [Pg.322]

The chemotaxis of mononuclear leukocytes and the migration, growth, and activation of the multiple cell types within atherosclerotic lesions are critical for the chronic inflammatory and fibroproliferative response in atherosclerosis (Ml). Chemokine-mediated attraction of leukocytes to tissues has been shown in atherosclerotic lesions (G8). Studies using knockout and transgenic murine models indicated that chemokine receptor/ligand interactions are crucial in the development of atherosclerosis (P6). Moreover, chemokines may also interfere with smooth muscle cell migration and growth, and platelet activation and other well-defined features of the atherosclerotic process (A2). [Pg.20]

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