Chemicals local trauma

Hexanone has also been shown to potentiate the neurotoxic effects of some compounds. In hens, dermal or inhalation exposure to 2-hexanone in combination with dermal application of the pesticide O-ethyl-O-4-nitrophenyl phenylphosphonothioate (EPN) has resulted in earlier onset and far more severe clinical and histological manifestations of neurotoxic effects than with either chemical exposure alone (Abou-Donia et al. 1985a, 1985b). The authors speculated that this potentiation effect may have been due to induction of hepatic microsomal cytochrome P-450 by EPN, leading to increased metabolism of 2-hexanone to its neurotoxic metabolite, 2,5-hexanedione. An alternate explanation is that local trauma to the nervous tissue produced by 2-hexanone and EPN might increase vascular permeability and thus increase the entry of these compounds and their metabolites from circulation. 

Persons with symptoms of radiation exposure Patients should be transported urgently to a specialized hospital after appropriate medical care. Experience has shown that localized external exposure, often without radioactive contamination, is the most common consequence of radiological accident. In most cases, the treatment can be offered in hospital units specifically identified for this purpose as part of a medical emergency plan. Persons with combined injuries radiation plus conventional trauma) Treatment of such patients has to be individualized in accordance with the nature and grade of the combined injury. Usually, a combination of radiation exposure with mechanical, thermal, or chemical injuries may worsen prognosis. 

Brain injuries can occur due to a wide range of internal and external factors, such as trauma, chemicals, ischaemia and haemorrhage. Unlike peripheral nervous system injury, neurons in the brain have a quite limited capacity to replace lost ones, and therefore complete functional restoration is not possible in most clinical cases. Immediately following injury, acute inflammatory response occurs accompanying the disruption of local blood vessels and death of... 

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