Chemical delivery system strategy

Silva et al. (2006) studied starch-based microparticles as a novel strategy for tissue engineering applications. They developed starch-based microparticles, and evaluated them for bioactivity, cytotoxicity, ability to serve as substrates for cell adhesion, as well as their potential to be used as delivery systems either for anti-inflammatory agents or growth factors. Two starch-based materials were used for the development of starch-based particulate systems (1) a blend of starch and polylactic acid (SPLA) (50 50 w/w) and (2) a chemically modifled potato starch, Paselli II (Pa). Both materials enabled the synthesis of particulate systems, both polymer and composite (with BG 45S5). A simple solvent extraction method was employed for the synthesis of SPLA and SPLA/BG microparticles, while for Pa and Pa/BG... 

Classic in vitro cell culture models were used earlier to test the permeability of drugs themselves (9). Nowadays, these systems display not only an alternative to animal testing in respect to ethical concerns, but are also applied as advanced models to develop new delivery strategies and to study drug delivery properties of nanoparticulate carriers or chemical delivery enhancers. Thereby, interactions with the biological barrier, specifically binding, uptake, and transport can be evaluated in a well-defined and standardized system. While oral delivery of drugs is still the commonly used and most accepted method of choice due to the... 

Full lifecycle costing has not been applied to the delivery of alternative fuels. Any strategy to select appropriate delivery systems should involve full lifecycle valuation of the options. Lifecycle cost analyses should compare gaseous and liquid hydrogen delivery and hydrogen carrier media such as metal and chemical hydrides, methanol, and ammonia. Multiple delivery infrastructures may be essential, which could add to the price of transitioning to a hydrogen economy. 

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