Drug-delivery properties

Classic in vitro cell culture models were used earlier to test the permeability of drugs themselves (9). Nowadays, these systems display not only an alternative to animal testing in respect to ethical concerns, but are also applied as advanced models to develop new delivery strategies and to study drug delivery properties of nanoparticulate carriers or chemical delivery enhancers. Thereby, interactions with the biological barrier, specifically binding, uptake, and transport can be evaluated in a well-defined and standardized system. While oral delivery of drugs is still the commonly used and most accepted method of choice due to the... 

In order to achieve the potential clinical benefits that can be provided by a formulation, as exemplified in Table 7.1, biopharmaceutical input is needed from the start of preformulation, through formulation development, to documentation for regulatory applications. The main objective is to obtain and verify desirable drug delivery properties for a pharmaceutical formulation. The key activities are as follows ... 

Others have paid particular attention to the preparation of a SWNT/CHT film by the solution-cast method, then characterised its drug delivery properties. They found out that the the release of dexamethasone from the film was slowed down in the presence of SWNT compared with the release rate from pure CHT films. 

Some hydrogels, due to their water content, provide a more flexible structure that is similar to soft tissue. Therefore, by combining the pol5uners that lack certain required mechanical properties such as a suitable modulus of rigidity or modulus of elasticity with hydrogels, suitable degradation and drug delivery properties are obtainable and an exterior is achieved that has mechanical properties similar to the mechanical properties of soft tissue. 

A potential mucoadhesive effect of GMO has been used as a rationale to develop GMO-based particles for administration to mucosal surfaces such as present in the GI tract. The interaction of simple, GMO/PX407-based cubosomes with mucin and mucin-coated surfaces was, however, weak. Modification of the cubo-some surface by the adsorption of chitosan led to an increased interaction with mucin-coated surfaces and may thus be an option to improve the drug delivery properties of such particles. Whether surface modification by chitosan adsorption has an effect on the internal structure of the particles remains, however, to be clarified. 

N. Blanchemain, Y. Karrout, N. Tabary, C. Neut, M. Bria, J. Siepmann, H.F. Hildebrand, and B. Martel, Methyl-()-cyclodextrin modified vascular prosthesis Influence of the modification level on the drug delivery properties in different media, Acta Biomater., 7 (1), 304-314, 2011. 

Boschin, F., Blanchemain, N., Bria, M., Delcourt-Debruyne, E., Morcellet, M., Hildebrand, H.F., et al, 2006. Improved drug delivery properties of PVDF membranes functionalized with P-cyclodextrin—application to guided tissue regeneration in periodontology. J. Biomed. Mater. Res., Part A 79A (1), 78-85. 

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