Chelidonium

Natural chelidonic acid is obtained from the herb celandine Chelidonium majus). The synthesis from ethyl oxalate and acetone was first described by Claisen the process was simplified by Willstatter and Pummerer and further improved by Ruzicka and Fornasir.- The present procedure is modelled after that of the last-mentioned investigators. 

Chelidonium majus L. This much investigated plant contains... 

This sub-group includes four alkaloids, a-homochelidonine, chelidonine, chelerythrine, and sanguinarine, whose nuclear structure and interrelationships (formula I to IV) have been established. Three minor chelidonium alkaloids, oxychelidonine, methoxychelidonine and oxy-sanguinarine, whose association is implied by their names, are included. 

Chelerythrine, C2iHi,04N. H2O. (Items 4, 5, 6, 7, 43, 46, 60 list, p. 169). This base was isolated by Probst from the root of Chelidonium majus. It was probably first obtained in a pure state by Konig and Tietz, from the root of Sanguinaria canadensis. A process for the separation and purification of the alkaloids of Chelidonium majus roots is given by Schmidt and Selled... 

Fig. n Fiuorescence scan of a Chelidonium extract chromatogram track with ca 5 pg chelidonine (A) before and (B) after 1 h irradiation with short-wavelength UV light two new zones are apparent that were not previously detected [25, 26]. 

Quaternary alkaloids Chelidonium maius SiOj Aqueous buffered MeOH UV 355 nm — 7... 

FIGURE 11.22 Densitograms illustrating the effect of sample dilution with methanol. System silica/T + AcOEt -l- MeOH (83 15 2). Plates triple developed (a) 2 mg of Chelidonium majus extract dissolved in 0.2 ml of methanol (b) 2 mg of the extract dissolved in 1.6 ml of methanol. For abbreviations, see Figure 11.16. (For details, see Waksmundzka-Hajnos, M., Gadzikowska, M., and Hajnos, M.., J. Planar Chromatogr., 15, 289-293, 2002.)... 

Figure 11.28 shows densitograms from the separation of Chelidonium majus quaternary alkaloids [114]. It is clearly apparent that multiple development results in better separation of the component bands. Threefold development results in separation or partial separation of eight alkaloid bands (Figure 11.28b), whereas after one run, only four zones — chelirubine, sanguinarine, chelilutine, and chelerithrine... 

Sanguinarine Chelidonium majus Corydalis ophiocarpa Eschscholzia califomica Fumaria cordata Macleaya cordata... 

VavreCkova, C., Gawlik, I. and MUller, K. 1996. Benzophenanthridine alkaloids of Chelidonium majus. I. Inhibition of 5- and 12-lipoxygenase by a non-redox mechanism. Planta Medica, 62 397-401. 

Lenfeld, J., Kroutil, M., Marsalek, E., Slavik, J Preininger, V. and Simanek, V. 1981. Anti-inflammatory activity of quaternary benzophenanthridine alkaloids from Chelidonium majus. Planta Medica, 43 161-165. 

Chelidonium album L. C. hybridum L. C. majus L. C. serotinum L. Bai Qu Cai (Celandine poppy) (whole plant) Chelidonine, chelidocystatin, protopine, stylopine, allocryptopine, chelerythrine, sparteine, coptisine.33-256-449-497 Anodyne, analgesic, diuretic, antitussive, detoxicant, anticancer. Treat abdominal pain, peptic ulcers, chronic bronchitis, and whooping cough. 

Rogelj, ., T. Popovic, A. Ritonja, B. Strukelj, and J. Brzin. 1998. Chelidocystatin, a novel phytocystatin from Chelidonium majus. Phytochemistry 49 1645-1649. 

Kim, D. J., B. W. Ahn, B. S. Han, and H. Tsuda. 1997. Potential preventive effects of Chelidonium majis L. (Papaveraceae) herb extract on glandular stomach tumor development in rats treated with V-methyl-V -nitro-V nitrosoguanidine (MNNG) and hypertonic sodium chloride. Cancer Lett. 112 203-208. 

Chelidonium album, C. hybridum, C. majus, C. serotinum, Macleaya cordata Chelidonium album, C. hybridum, C. majus, C. serotinum Chelidonium album, C. hybridum, C. majus, C. serotinum Macleaya cordata... 

Chelidonium album, C. hybridum, C. majus, C. serotinum, Cytisus scoparius... 

Berberis vulgaria, B. aquifolium, Chelidonium majus, Coptis chinensis, C. groenlandica, C. trifolia, Mahonia aquifolium, Phellodendron amurense, P. chinensis Berberis vulgaria Apium graveolens Cuscuta chinensis, C. epithymum... 

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