Cervical imaging

Fig. 4.1. Multiphoton fluorescence intensity (A-C) and TCSPC fluorescence lifetime images (D-F) of fresh unstained sections of human cervical biopsy excited at 740 nm and imaged between 385 and 600 nm. The individual acquisition times were 600 s. Adapted from Fig. 22.11 of Ref. [8].

Evaluating recurrent or residual follicular cell tumors (treated previously by thyroidectomy and radioiodine ablation) when serum thyroglobulin >10 ng/ml and 2 1 whole-body scan is negative (October 2003) Detecting pretreatment metastases in newly diagnosed cervical cancer after negative conventional imaging (January 2005)... 

FIGURE 8.8 A section of a single HeLa (human cervical cancer) cell stained with Phalloidin 350 (actin filaments) and MitoTracker488 (mitochondria) acquired using selective two-photon excitation, without fluorescence color filters. The image size is about 25 (xm. (From Dantus, M., Lozovoy, V. V., and Pastirk, I. Laser Focus World, 43(5) 101-104. 2007. Used with permission.)... 

Applications of FTIR tissue imaging to cervical cancer... 

FTIR focal plane array imaging of cervical tissue... 

Having shown that IR imaging and UHCA analysis is capable of extracting mean spectra for the major cell types in cervical tissue samples, there are a number of remaining goals for the cervical cancer work. First, we wish to develop a methodology to determine the optimum number of clusters in any analysis that... 

Bambery, K., Wood, B. R., Quinn, M. A. and McNaughton, D. (2004) Fourier Transform Infrared Imaging and Unsupervised Hierarchical Clustering applied to cervical Biopsies. Aust J. Chem. 57, 1139-43. 

Brown E, Virapongse C, and Gregorios JB (1998) MR imaging of cervical spinal cord infarction. J Comput.Assist.Tomogr. 13 (5) 920-922... 

Lamy C, Giarmesini C, Zuber M et al. (2002). Clinical and imaging findings in cryptogenic stroke patients with and without patent foramen ovale the PFO-ASA Study (Atrial Septal Aneurysm). Stroke 33 706-711 Leung SY, Ng THK, Yuen ST et al. (1993). Pattern of cerebral atherosclerosis in Hong Kong Chinese severity in intracranial and extracranial vessels. Stroke 24 779-786 Leys D, Moulin Th, Stojkovic T et al. (1995). Follow-up of patients with history of cervical artery dissection. Cerebrovascular Diseases 5 43-49... 

A similar trade-off between diagnostic accuracy and risk is necessary when imaging the carotid bifurcation in patients with TIA or ischemic stroke. Performing intra-arterial catheter angiography in everyone is clearly unacceptable because of the risks and cost. Fewer than 20% of patients will have an operable carotid stenosis even if only those with cortical rather than lacunar events are selected (Hankey and Warlow 1991 Hankey et al. 1991 Mead et oL 1999). Coirfining angiography to patients with a carotid bifurcation bruit will miss some patients with severe stenosis and still subject too many with mild or moderate stenosis to the risks. Nor will a combination of a cervical bruit with various clinical features do much better (Mead et al. 1999). 

Figure 18.1. MRI signal abnormalities in the brain and spinal cord in a 55-year-old woman with multiple sclerosis. (A) FLAIR (Fluid attenuated inversion recovery) image of axial brain image at the level of the lateral ventricles. Arrows point to hyperintense periventricular lesions demonstrating a characteristics MS demyelination pattern (B) T2W image of sagittal view of the spinal cord of the same individual, demonstrating focal bright signal (arrow) representing demyelination in the cervical spinal cord.

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