Cerebrovascular disease and

Traditional CNS stimulants have the potential to increase blood pressure and heart rate when used long term. In addition, excessive CNS stimulation can cause tremors and tics and can carry over into evening hours, where initiation of normal nighttime sleep can be disrupted. Caution should be used in patients with underlying cardiovascular or cerebrovascular disease and in patients with a history of seizures because stimulants may lower the seizure threshold. 

Contraindications include ischemic heart disease, uncontrolled hypertension, cerebrovascular disease, and hemiplegic and basilar migraine. Trip-... 

Persistence of risk-An increased risk may persist for 6 years or more after discontinuation of OC use for cerebrovascular disease and 9 years or more for Ml in users 40 to 49 years of age who had used OCs 5 years or more. This information is based on studies that used OCs containing 50 meg estrogen or more. 

Estrogen therapy may increase the risk of developing coronary heart disease, hypercalcemia, gallbladder disease, cerebrovascular disease, and breast cancer. 

Erkinjuntti T, Kurz A, Gauthier S et aL (2002). Efficacy of galanthamine in probable vascular dementia and Alzheimer s disease combined with cerebrovascular disease a randomised trial. Lancet 359 1283-1290 Esiri MM, Nagy Z, Smith MZ et al. (1999). Cerebrovascular disease and threshold for dementia in the early stages of Alzheimer s disease. Lancet 354 919-920 Folstein ME, Robins LN, Helzer JE (1983). 

Acetazolamide toxicity was suspected, because of the temporal association between drug treatment and the onset of the neurological sjmptoms, together with metabolic acidosis. Gerstmann sjmdrome is usually due to an acute stroke. Although a brain CT scan was negative, such an event was likely in this patient, who had a history of cerebrovascular disease and multiple risk factors, and a causal relation to acetazolamide must be considered tenuous. 

Naftidrofuryl has been marketed in Europe for over 20 years for the treatment of peripheral and cerebrovascular diseases and for senile dementia (1). A few placebo-controlled studies have reported increases in... 

Transient cerebral ischemic attacks, unrelated to blood pressure changes, occurred with isosorbide dinitrate and glyceryl trinitrate ointment in a patient with previous cerebrovascular disease, and resolved on withdrawal... 

Sethi, R., and Haque, W., Pyridoxal-5 -phosphate, pyridoxal, pyridoxine, pyridoxamine, and related analogs for the treatment of cerebrovascular disease, and preparation of compounds, Medicure, Int. Patent Appl. WO 2001072309. 2001 Chem. Abstr, 135, 267243, 2001. 

Patients with pre-existing heart disease, cerebrovascular disease, and hypertension should be closely monitored during treatment most cardiovascular complications occur within the first 2 months to 1 year of treatment low-dose warfarin (1-2 mg/day) is commonly used to decrease risk of thromboembolic events, but its value is not proven Doses should be taken on an empty stomach (1 hour before or 2 hours after a meal) avoid concurrent administration with dairy products or calcium compounds refrigerate... 

Alginic sodium diester (ASD) is made from sodium alginate extracted from seaweed. It is an important medicine in China, and is widely used to cure ischemic cardiovascular and cerebrovascular diseases and hyperlipemia, based on its functions of reducing viscosity, resisting coagulation and improving circulation of blood. 

Diagnosis of cerebrovascular disease and differentiation of focal abnormalities in CBF typical in multi-infarct dementia and degenerative dementia... 

Hyperlipidemia is a major cause of atherosclerosis and atherosclerosis-associated conditions, such as coronary heart disease (CHD), ischemic cerebrovascular disease, and peripheral vascular disease. These conditions account for most morbidity and mortality among middle-aged and older adults. DysUpidemias, including hyperhpidemia (hypercholesterolemia) and low levels of high-density-hpoprotein cholesterol (HDL-C), are major causes of increased atherogenesis both genetic disorders and lifestyle (sedentary behavior and diets high in calories, saturated fat, and cholesterol) contribute to the dysUpidemias seen in developed countries. 

King A, Markus HS Doppler embolic signals in cerebrovascular disease and prediction of stroke risk, a systematic review and meta-analysis. Stroke 2009 40 pp. 3711-3717. 

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