Centrocytic lymphoma

W7. Williams, M. E., Swerdlow, S. H., Rosenberg, C. L., and Arnold, A., Chromosome 11 translocation breakpoints at the PRADl/cyclin D1 gene locus in centrocytic lymphoma. Leukemia 7,... 

Centrocytic lymphomas These have their origin in lymphatic germ centre cells. Liver involvement occurs in about 50% of patients. The portal infiltrates consist of small cells with bright, irregularly shaped, indented nuclei. The portal fields are globularly distended as a result of the infiltration the limiting plates remain intact, however, and the portal bile ducts are also undamaged. 

A 73-year-old man with a 5-year history of centrocytic non-Hodgkin s lymphoma presented with subcutaneous nodules in the abdominal wall at the sites where he had previously received subcutaneous injections of mistletoe (6). The nodules turned out to be infiltrations by the centrocytic lymphoma. The patient died 6 weeks later of bilateral pneumonia. The authors hypothesized that mistletoe has a growth-promoting action on lymphoma cells, mediated by high local concentrations of mterleukin-6 liberated from the skin by mistletoe lectins. 

Fraga M, Lloret E, Sanchez-Verde L, et al. Mucosal mantle cell (centrocytic) lymphomas. Histopathology. 1995 26(5) 413-422. 

Mantle cell lymphoma is a lymphoma arising from immature B-cells of the primary follicles and mantle zone of peripheral lymphoid organs, whereas the final malignant transformation seems to take place in the mature B-cell after antigen stimulation. Mantle cell lymphoma is described in the Kiel classification as centrocytic lymphoma and listed in the WHO classification as mantle cell lymphoma. This lymphoma type makes 5-10% of all lymphomas, characterized by nodular and/or diffuse proliferation of small to medium sized neoplastic lymphoid cells with coexpression of B-cell-associated antigens and CD5. Mantle cell lymphoma occurs mainly in older adults with a high male female ratio and shows low sensitivity to chemotherapy with a median survival less than 5 years. 

Follicular Lymphoma (FL). These tumors are indolent, primarily nodal, lymphomas and are composed of a mixture of centrocytes and centro-blasts. These lymphomas are graded based on the number of centroblasts, which are the proliferating cells. 

H12. Harris, N. L., Nadler, L. M., and Bhan, A. K., Immunohistologic characterization of two malignant lymphomas of germinal center type (centroblastic/centrocytic and centrocytic) with monoclonal antibodies. Follicular and diffuse lymphomas of small-cleaved-cell type are related but distinct entities. Am. J. Pathol. 117, 262-272 (1984). 

Swerdlow SH, Yang WI, Zukerberg LR, et al. Expression of cyclin D1 protein in centrocytic/mantle cell lymphomas with and without rearrangement of the BCLl/cyclin D1 gene. Hum Pathol. 1995 26(9) 999-1004. 

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