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Regulation, cellular, schematic

Figure 31-18 Schematic representation of the subunit structure of ferritins from various tissues. (From Harrison PM, Arosh P. The ferritins molecular properties, iron storage function and cellular regulation. Biochim Biophys Acta 1996 12 75 161-203.)... Figure 31-18 Schematic representation of the subunit structure of ferritins from various tissues. (From Harrison PM, Arosh P. The ferritins molecular properties, iron storage function and cellular regulation. Biochim Biophys Acta 1996 12 75 161-203.)...
Figure 15 schematizes the central regulatory role of G proteins in regulation of cellular metabolism in response to extracellular signals. The three most immediate questions that emerge from this scheme and the above discussions follow ... [Pg.37]

Figure 13 Schematic showing the current understanding of the mechanism of action of HPMA copolymer-anticancer conjugates at the (a) whole organism level, (b) the cellular level, and (c) the molecular level. The exact molecular mechanisms leading to cytostatic and cytotoxic action are not conclusively proven (see discussion in the text), so suggested molecular mechanisms are illustrated and the possible up- and down-regulation of molecular markers indicated. Figure 13 Schematic showing the current understanding of the mechanism of action of HPMA copolymer-anticancer conjugates at the (a) whole organism level, (b) the cellular level, and (c) the molecular level. The exact molecular mechanisms leading to cytostatic and cytotoxic action are not conclusively proven (see discussion in the text), so suggested molecular mechanisms are illustrated and the possible up- and down-regulation of molecular markers indicated.
The activity of multi-cellular organisms like higher plants depends on the Interaction of a number of regulatory systems which can be represented schematically by a sequence of regulators, first that of a cell (gene, chromosome, nucleus, cytoplasm), then of a tissue and. [Pg.13]

FIGURE 3.3.1 Schematic representations of environmental factors that regulate cellular activities. [Pg.116]

Figure 1 Schematic representation of regulation by NADPH oxidase of K channel activity, (a) In normoxia, NADPH oxidase tonically generates hydrogen peroxide (H2O2) fiom atmospheric O2. This H2O2 promotes channel activity, (b) In hypoxia, O2 levels are limited and H2O2 production is reduced, resulting in channel closure and cell depolarization, (c) Upon activation of NADPH oxidase by protein kinase C (PKC)-mediated phosphorylation, substrate (molecular O2) affinity is increased with the result that cellular H2O2 production is sustained diuing hypoxia and channel activity is maintained. Figure 1 Schematic representation of regulation by NADPH oxidase of K channel activity, (a) In normoxia, NADPH oxidase tonically generates hydrogen peroxide (H2O2) fiom atmospheric O2. This H2O2 promotes channel activity, (b) In hypoxia, O2 levels are limited and H2O2 production is reduced, resulting in channel closure and cell depolarization, (c) Upon activation of NADPH oxidase by protein kinase C (PKC)-mediated phosphorylation, substrate (molecular O2) affinity is increased with the result that cellular H2O2 production is sustained diuing hypoxia and channel activity is maintained.
The molecular regulation of cellular cholesterol metabolism has been elucidated by Brown and Goldstein [64]. Cholesterol is synthesized in the hver by the enzyme HMG-CoA reductase. Subsequently, it is transformed into bile acid in the liver and secreted to the gall bladder. The statins inhibit HMG-CoA reductase, which is a key rate-limiting enzyme in cholesterol biosynthesis. The effective removal of the bile acid from the bile pool is another viable approach to reduce plasma LDLc. Removal of bile acid from the body results in upregulation of bile acid biosynthesis, which subsequently leads to a corresponding overall drop in plasma cholesterol levels [65]. The biochemical process of cholesterol metabolism is schematically illustrated in Fig. 6. [Pg.25]

In this chapter we intend to describe briefly the structure and the main biochemical functions of the individual cellular components and to point out some principles of regulation. Knowledge of the individual reaction sequences and cycles (respiratory chain, glycolysis, citrate cycle, etc.) is a prerequisite. When in doubt, refer to the fold-out chart at the back of the book. A schematic diagram of cellular organization is presented in Fig. 47. [Pg.323]


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Regulation, cellular

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