Drug delivery cell-specific

D. K. F. Meijer and P. J. Swart, Isolated perfused liver as a tool to study the disposition of peptides, liver first-pass effects, and cell-specific drug delivery, J. Contr. Rel. 46 139-156 (1997). 

One difficulty with the cytotoxic agents that are used for the treatment of cancer is the differentiation of cytotoxicity between target tumor cells and normal cells. In an innovative approach, the Wyeth group took advantage of a tumor cell-specific drug delivery mechanism of antibodies. They conjugated calicheam-icin (93), perhaps the best described member of the ene-diyne... 

Cao Z, Tong R, Mishra A, Xu W, Wong GC, Cheng J et al. Reversible cell-specific drug delivery with aptamer-functionalized liposomes. Angewandte Chemie International Edition. 2009 48(35) 6494-6498. Sihorkar V, Vyas S. Potential of polysaccharide anchored liposomes in drug delivery, targeting and immunization. Journal of Pharmacy and Pharmaceutical Science. 2001 4(2) 138-158. 

E. Tomlinson, (Patho)physiology and the temporal and spatial aspects of drug delivery, in Site-Specific Drug Delivery. Cell Biology, Medical, and Pharmaceutical Aspects (E. Tomlinson and S. S. Davis, eds.), John Wiley Sons. Chichester, 1986, p. 1. 

Voinea, M., Manduteanu, I., Dragomir, E., Capraru, M., and Simionescu, M. (2005), Immunoliposomes directed toward VCAM-1 interact specifically with activated endothelial cells—a potential tool for specific drug delivery, Pharm. Res., 22,1906-1917. 

Dunn, S. E., Brindley, A., Davis, S. S., Davies, M. C., and Ilium, L. (1994), Polystyrene-poly (ethylene glycol) (PS-PEG2000) particles as model systems for site specific drug delivery. 2. The effect of PEG surface density on the in vitro cell interaction and in vivo biodistribution, Pharm. Res., 11,1016-1022. 

Hopkins CR. Site-specific drug delivery-cellular opportuiuties and challenges. In Tomlinson E, Davis SS, eds. Site-Specific Drag Delivery, Cell Biology, Medical and I armaceutical Aspects. Chichester, U.K. John Wiley Sons, 1886 27. 

Meijer DKF, Sluijs PVD. Covalent and noncovalent protein binding of drugs implications for hepatic clearance, storage, and cell-specific drag delivery. Pharm Res 1989 6 105-118. 

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