Implicated Drugs

Hapten-dependent antibody Drag (hapten) links covalcmtly to monbiane protein and induces a drag-specific immune response Penicillin, cephalosporin antibiotics  

Drag-depoident antibody Drug induces antibody that binds to membrane protein only in the presence of soluble drag Quinine, many antibiotics, non-steroidal antiinflammatory drags, anticonvulsants 

Fiban-induced ihrombocytopenia Drag (ligand) reacts with membrane glycoprotein Ilb/lIIa and induces a conformational change recognized by antibody Epitifibatide, tirofiban 

Drag-specific antibody Antibody is specific for the murine component of a chimeric Fab fragment that binds to platelet GPIIb/lIIa Abciximab 

Autoantibody induction Drag induces antibody that reacts with platelets in the absence of drag. Gold salts, L-Dopa, procainamide 

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Lynskey MT The comorbidity of alcohol dependence and affective disorders treatment implications. Drug Alcohol Depend 52 201-209, 1998... 

Harman, D. (1993). Free radical involvement in aging. Pathophysiology and therapeutic implications. Drugs Aging 3, 60-80. 

Presentation Skin Lesions Involvement Implicated Drugs Treatment... 

B.K. Park, N.R. Kitteringham, Effects of fluorine substitution on drug metabolism Pharmaceutical and toxicological implications, Drug Metab. Rev. 26 (1994) 605-643. 

Hoozemans, J.J.M., Veerhuis, R, Rozemuller, AJ.M., Eikelenboom, P The pathological cascade of Alzheimer s disease the role of inflammation and its therapeutic implications. Drugs Today 38, 429-443, 2002. 

Lewis, D.F.V. (1999) Frontier orbitals in chemical and biological activity quantitative relationships and mechanistic implications. Drug Metab. Rev., 31 (3), 755-816. 

The possible drug-induced causes of ANCA-positive vasculitis with high titers of antimyeloperoxidase antibodies in 30 new patients have been reviewed (65). The findings illustrated that this type of vasculitis is a predominantly drug-induced disorder. Only 12 of the 30 cases were not related to a drug. The most frequently implicated drug was hydralazine (n = 10) the remainder involved propylthiouracil (n = 3), penicillamine (n = 2), allopurinol (n = 2), and sulfasalazine (n = 1). 

Clark DWJ. Genetically determined variability in acetylation and oxidation. Therapeutic implications. Drugs 1985 29 342-375. 

Sporer KA. The serotonin syndrome. Implicated drugs, pathophysiology and management. Drug Saf 1995 13(2) 94—104. 

Greener, M. Drug transporters and ADME pharmacological and commercial implications. Drug and market development publications market analysis report. Westborough, MA, 2003. 

Two cases of drug allergy have been reported in a 37-year-old woman and a 66-year-old man, who received hydroxyzine for premedication before anesthesia (1,2). In these patients immediate skin tests with the implicated drug were positive. 

Melkcrsson, K. and M. L. Dahl (2004). Adverse metabobc effects associated with atypical antipsychotics literature review and clinical implications. Drugs 64(7) 701-23. 

Ferrari P, Bianchi G. The genomics of cardiovascular disorders therapeutic implications. Drugs 2000 S9 1025 42. 

Mannel M. Drug interactions with St. John s wort mechanism and clinical implications. Drug Saf 2004 27 773-797. 

Clinical Presentation Pattern and Distribution of Skin Lesions Mucous Membrane Involvement Implicated Drugs Treatment... 

Inconsistencies in the identification of antibodies to medication have made it difficult to implicate drugs as the main determinant for the... 

The third mechanism described for drug-induced thrombocytopenia is the innocent bystander-type immune response. The most commonly implicated drug is quinidine, and the drug-induced thrombocytopenia is frequently related to higher doses of the drug. Quinidine may also form a hapten with the platelet membrane to produce thrombocytopenia. ... 

Hempel E, Klinger W. Drug stimulated biotransformation of hormonal steroid contraceptives clinical implications. Drugs (1976) 12, 442-8. 

Waddell, D.D. 2007. Viscosupplementation with hyaluronans for osteoarthritis of the knee chnical efficacy and economic implications. Drugs Aging 24(8), 629-642. 

Mannel M (2004) Drug interactions with St John s wort mechanisms and clinical implications. Drug Saf27 773-797... 

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