Signal transduction networks

The mDHFR protein complementation assay has been used to map a signal transduction network that controls the initiation of translation in eukaryotes (Remy and Michnick, 2001). A total of 35 different pairs of full-length proteins were analyzed and 14 interactions were identified using the survival selection of cells grown in the absence of nucleotides. In addition, the use of the fMTX reagent in combination with fluorescence microscopy was used to localize the protein complex within cells (Remy and Michnick, 2001). 

DNA damage-inducible cell cycle checkpoints are complex signal transduction networks that integrate the cellular responses to genotoxic insults by arresting cell cycle... 

Surh Y-J, Kundu JK. 2005. Signal transduction network leading to COX-2 induction A road map in search of cancer chemopreventives. Arch Pharm Res 28 1-15. 

T Lane, A Benson, GB Hecht, GJ Burton, A Newton. Switches and signal transduction networks in the Coulobacter crescentus cell cycle. In JA Hoch, TJ Silhavy, eds. Two-component signal transduction. Washington, DC ASM Press, 1995, pp 403-430. 

Figure 1 Partial representation of a signal transduction network, mediated by a cell surface receptor. The molecules are organized hierarchically (roughly, from top to bottom) according to their functions as adaptors, receptor-recruited enzymes, membrane-associated substrates, and effector kinases. Arrows represent activation mechanisms, whether by complex formation or covalent modification V bars indicate negative regulation.

Janes KA, Yaffe MB. Data-driven modelling of signal-transduction networks. Nat. Rev. Mol. Cell. Biol. 2006 7 820-828. 

Lok L, Brent R. Automatic generation of cellular reaction networks with Moleculizer 1.0. Nat. Biotechnol. 2005 23 131-136. Conzelmann H, Saez-Rodriguez J, Sauter T, Kholodenko BN, Gilles ED. A domain-oriented approach to the reduction of combinatorial complexity in signal transduction networks. BMC Bioinformatics 2006 7 34. 

Coarse-grained (phenomenological) level. Some other reduced model is adopted for the study of gene expression or signal transduction network. The modeling at this level is relevant when attempting to understand specific function of a cell. 

Gomez, S. M., S. H. Lo, and A. Rzhetsky. 2001. Probabilistic prediction of unknown metabolic and signal-transduction networks. Genetics 159 1291-8. 

Barkai, N., Alon, R. and Leibler, S. (2001). Robust amplification in adaptive signal transduction networks. C. K Acad. Sci. Paris Serie IV 2, 871-877. 

Rothman, D.M., Shults, M.D., and Imperial , B. (2005) Chemical approaches for investigating phosphorylation in signal transduction networks. Trends Cell... 

R267 S. Yatnada and Y. Shiro, Structural Basis of the Signal Transduction in the Two-Component System , in Advances in Experimental Medicine and Biology, ed. R. Utsumi, Springer, 2008, Vol. 631, Bacterial Signal Transduction Networks and Drug Targets, p. 22. 

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