Cell Contact guidance

The effect of the RACKl signalling protein on the regulation of cell adhesion and cell contact guidance on nanometric grooves. Biomaterials, 29, 282-289. 

Growth cones are subject to both chemoattractant and chemorepellent effects of guidance molecules and also to attraction or repulsion resulting from cell cell-contacts. To complicate the picture further, the netrins and also the brain-derived neurotrophic factor BDNF (see Fig. 30-6D) may first attract, and then after a period of adaptation or desensitization, repel a growth cone.4 13 4 4 446 443 Consecutive phases of desensitization and resensitization may result in a zig zag path of... 

Teixeira Al, Abrams GA, Bertics PJ, Murphy CJ, Nealey PF. Epithelial contact guidance on well-defined micro- and nanostructured substrates. J Cell Sci 2003 116 1881-92. 

Newgreen, D.F. (1989) Physical influences on neural crest cell migration in avian embryos contact guidance and spatial restriction. Dev. Biol. 131 136-148. 

Contact guidance The theory by which cells attach to and migrate on substrates of specific microstructure and topographic orientation. The abflity of the ceU to attach and migrate on a substrate is related to the cytoskeletal and attachment molecules present on the ceU membrane. 

J. Meyle, K. Giiltig, W. Nisch, Variation in contact guidance by human cells on a microstructured surface, J. Biomed. Mater. Res. 29 (1995) 81-88. 

Laco F, Grant MH, Black RA (2013) Collagen-nanofiber hydrogel composites promote contact guidance of human lymphatic microvascular endothelial cells and directed capillary tube formation. J Biomed Matiu Res A 101 1787-1799... 

Wilkinson PC, Lackie JM (1983) The influence of contact guidance on chemotaxis of human neutrophil leukocytes. Exp Cell Res 145 255-264... 

Orientation In the particular case of nerve guide substitutes engineering, orientation of fibers rightly scaled in a parallel distribution have shown to guide axon extension and Schwann cell growth by contact guidance on the surface without infiltration into the inner network while random fibrous mesh are infiltrated. 

Rajnicek AM, McCaig CD. Contact guidance of CNS neurites on grooved quartz influence of groove dimensions, neuronal age and cell type. J Cell Sci 1997 110 2915-24. 

Ohara, P.T. and Buck, R.C., Contact guidance in vitro. A Ught, transmission, and scanning electron microscopic study, Exp. Cell Res. 121,235-249,1979. 

Modification of polymer surfaces is used to improve biocompatibility or to provide medico-functionality of blood- and tissue-contacting medical devices. Yu et used Direct Laser Interference Patterning (DLIP) to prepare periodic micropatterns in polymers for study of contact guidance of mammalian cells. 

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