Guidance molecules

Somatic motor and sensory neurons that give rise to PNS axons maintain large fractions of their total protoplasmic bulk within the CNS. Many of the extracellular matrix components and axonal guidance molecules involved in... 

Growth cones are subject to both chemoattractant and chemorepellent effects of guidance molecules and also to attraction or repulsion resulting from cell cell-contacts. To complicate the picture further, the netrins and also the brain-derived neurotrophic factor BDNF (see Fig. 30-6D) may first attract, and then after a period of adaptation or desensitization, repel a growth cone.4 13 4 4 446 443 Consecutive phases of desensitization and resensitization may result in a zig zag path of... 

STRUCTURES OF AXON GUIDANCE MOLECULES AND THEIR NEURONAL RECEPTORS... 

Kolodkin, A. L., Matthes, D. J., and Goodman, C. S. (1993). The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. Cell 75, 1389-1399. 

Gussing F, Bohm S (2004) NQOl activity in the main and the accessory olfactory systems correlates with the zonal topography of projection maps.Eur J Neurosci 19(9) 2511—2518 Hanson MG, Landmesser LT (2004) Normal patterns of spontaneous activity are required for correct motor axon guidance and the expression of specific guidance molecules.Neuron... 

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